2956426-18-7
Chemical Structure
MAO-B-IN-21
- CAS No.: 2956426-18-7
- Formula:C24H25ClN2O4
- Molecular Weight:440.92
IUPAC Name: 5-(5-chloro-2-hydroxyphenyl)-2-(1-heptyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-2,4-dihydro-3H-pyrazol-3-one
InChIKey: VDMXTYVCJKLTGE-UHFFFAOYSA-N
SMILES: CCCCCCCC1OC(C2=CC(N3N=C(CC3=O)C4=CC(Cl)=CC=C4O)=CC=C21)=O
Biological Activity: MAO-B-IN-21 is an excellent MAO-B inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model[1].
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MAO-B-IN-21 | MAO-B-IN-21 is an excellent MAO-B inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model. | |||||||||||||||||||||
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Keywords
