TNF-α-IN-19
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β.
For research use only. We do not sell to patients.
- CAS No.: 338773-13-0
- Formula: C16H8ClF3N4
- Molecular Weight:348.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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IL-1β |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 2008 | IC50 |
2.5 μM
Compound: 7, LQ011
|
Cytotoxicity against human cDDP-sensitive 2008 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-sensitive 2008 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
|
[PMID: 20951595] |
| A2780 | IC50 |
2.3 μM
Compound: 7, LQ011
|
Cytotoxicity against human cDDP-sensitive A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-sensitive A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
|
[PMID: 20951595] |
| A2780 | IC50 |
4.7 μM
Compound: 7, LQ011
|
Cytotoxicity against human cDDP-resistant A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-resistant A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
|
[PMID: 20951595] |
| C13 | IC50 |
3.4 μM
Compound: 7, LQ011
|
Cytotoxicity against human cDDP-resistant C13 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-resistant C13 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
|
[PMID: 20951595] |
| Vero | IC50 |
1.2 μM
Compound: 7, LQ011
|
Cytotoxicity against african green monkey Vero cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against african green monkey Vero cells after 72 hrs using crystal violet staining by spectrophotometric analysis
|
[PMID: 20951595] |
Chemical Information
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CAS No. 338773-13-0
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Molecular Weight 348.71
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Formula C16H8ClF3N4
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SMILES
ClC1=CC=C(C2=NN=C3N2C4=C(N=C3C(F)(F)F)C=CC=C4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)