338773-13-0
338773-13-0
Chemical Structure
TNF-α-IN-19
- CAS No.: 338773-13-0
- Formula:C16H8ClF3N4
- Molecular Weight:348.71
IUPAC Name: 1-(4-chlorophenyl)-4-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
InChIKey: PEOTYDSXVIEYAM-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C2=NN=C3N2C4=C(N=C3C(F)(F)F)C=CC=C4)C=C1
Biological Activity: TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β[1].
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TNF-α-IN-19 | TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β. | |||||||||||||||||||||
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References
Keywords
