FGA139
FGA139 is a cysteine proteases inhibitor with IC50 values of 4.98/3.14 μM for cathepsin B/L. FGA139 reduces LPS-induced NO production in RAW264.7 cells and tumor necrosis factor (TNFα) levels in microglia, and has anti-oxidative stress and anti-inflammatory activities. FGA139 promotes the secretion of neuroprotective metabolites purine and linoleic acid by LPS-stimulated microglia. FGA139 can be used in neuroinflammatory diseases research.
For research use only. We do not sell to patients.
- Formula: C48H58BF2N7O5
- Molecular Weight:861.83
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Cathepsin Isoforms
More
Biological Activity
Chemical Information
-
Molecular Weight 861.83
-
Formula C48H58BF2N7O5
-
SMILES
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(/C=C/C(OCC)=O)=O)=O)[C@@H](N2N=NC(CCCCC3=C4[N+]([B-](F)(F)N5C3=C(C)C=C5C)=C(C)C=C4C)=C2)CC6=CC=CC=C6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz