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  3. Cot inhibitor-2

Cot inhibitor-2 

Cat. No.: HY-32018 Purity: 99.22%
Handling Instructions

Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM.

For research use only. We do not sell to patients.

Cot inhibitor-2 Chemical Structure

Cot inhibitor-2 Chemical Structure

CAS No. : 915363-56-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 328 In-stock
Estimated Time of Arrival: December 31
2 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 276 In-stock
Estimated Time of Arrival: December 31
10 mg USD 444 In-stock
Estimated Time of Arrival: December 31
25 mg USD 912 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1620 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2640 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM[1].

IC50 & Target

COT/Tpl2[1]

In Vivo

Cot inhibitor-2 (compound 34) is orally administered in rats with 100 mg/kg dosing and showed a Cmax of 517 ng/mL (0.89 μM) and AUC of 4841 ng•h/mL. Cot inhibitor-2 is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats. With a 25 mg/kg po dose, Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

539.43

Formula

C₂₆H₂₅Cl₂FN₈

CAS No.

915363-56-3

SMILES

N#CC1=C(C2=CC(NCC3=CN(N=N3)C4CCN(CC4)CC)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (185.38 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8538 mL 9.2690 mL 18.5381 mL
5 mM 0.3708 mL 1.8538 mL 3.7076 mL
10 mM 0.1854 mL 0.9269 mL 1.8538 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (5.56 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (5.56 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.22%

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Keywords:

Cot inhibitor-2Cot inhibitor2Cot inhibitor 2MAP3KMAP kinase kinase kinase, MEKK, MAPKKKTpl2cotMAP3K8wholebloodTNF-αLPSInhibitorinhibitorinhibit

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Product Name:
Cot inhibitor-2
Cat. No.:
HY-32018
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