915363-56-3
915363-56-3
Chemical Structure
Cot inhibitor-2
- CAS No.: 915363-56-3
- Formula:C26H25Cl2FN8
- Molecular Weight:539.43
IUPAC Name: 8-chloro-4-((3-chloro-4-fluorophenyl)amino)-6-(((1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methyl)amino)quinoline-3-carbonitrile
InChIKey: PHNZIIMWDVXPGG-UHFFFAOYSA-N
SMILES: N#CC1=C(C2=CC(NCC3=CN(N=N3)C4CCN(CC4)CC)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5
Biological Activity: Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cot inhibitor-2 | 99.65% | Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM. | ||||||||||||||||||||
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References
Keywords
