2. Apoptosis
  3. TNF Receptor
  4. TACE-IN-1

TACE-IN-1 is an orally active hydantoin-based tumor necrosis factor-α converting enzyme (TACE) inhibitor. TACE-IN-1 inhibits the production of TNF-α in human whole blood. TACE-IN-1 can be prepared as a stable neutral form. TACE-IN-1 can be used in anti-inflammatory research.

For research use only. We do not sell to patients.

TACE-IN-1

TACE-IN-1 Chemical Structure

CAS No. : 1219812-22-2

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TACE-IN-1 Related Antibodies

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View All TNF Receptor Isoform Specific Products:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

TACE-IN-1 is an orally active hydantoin-based tumor necrosis factor-α converting enzyme (TACE) inhibitor. TACE-IN-1 inhibits the production of TNF-α in human whole blood. TACE-IN-1 can be prepared as a stable neutral form. TACE-IN-1 can be used in anti-inflammatory research[1].

In Vitro

TACE-IN-1 (1 h pre-incubation; 3.5 h post-LPS addition) inhibits TNF-α production in human whole blood with an IC50 of 281 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TACE-IN-1 Related Antibodies
Parmacokinetics
Species Dose Route F AUC
Rat[1] 10 mg/kg p.o. 74 % 13.1 μM·h
Monkey[1] 3 mg/kg p.o. 92 % /
Dog[1] 3 mg/kg p.o. 72 % /
Rat[1] 100 mg/kg p.o. / 210 μM·h
Rat[1] 300 mg/kg p.o. / 780 μM·h
Rat[1] 500 mg/kg p.o. / 1450 μM·h
Molecular Weight

506.52

Formula

C26H26N4O7
CAS No.
SMILES

C([C@@]1(C(=O)N(COC(C(C)(C)C)=O)C(=O)N1)C2=CC=3C(O2)=CC=CN3)N4C(=O)C=5C(C4)=CC=C(OC)C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TACE-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TACE-IN-11219812-22-2TNF ReceptorTumor Necrosis Factor ReceptorTNFRTACE inhibitorInhibitorinhibitorinhibit

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