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Cat. No.: HY-153504

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TACE-IN-1

TACE-IN-1 is an orally active hydantoin-based tumor necrosis factor-α converting enzyme (TACE) inhibitor. TACE-IN-1 inhibits the production of TNF-α in human whole blood. TACE-IN-1 can be prepared as a stable neutral form. TACE-IN-1 can be used in anti-inflammatory research.

For research use only. We do not sell to patients.

CAS No.: 1219812-22-2
Formula: C₂₆H₂₆N₄O₇
Molecular Weight:506.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TACE-IN-1 Chemical Structure

CAS No.: 1219812-22-2

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Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All TNF Receptor Isoforms :

In Vitro

TACE-IN-1 (1 h pre-incubation; 3.5 h post-LPS addition) inhibits TNF-α production in human whole blood with an IC₅₀ of 281 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	F	AUC
Rat^[1]	10 mg/kg	p.o.	74 %	13.1 μM·h
Monkey^[1]	3 mg/kg	p.o.	92 %	/
Dog^[1]	3 mg/kg	p.o.	72 %	/
Rat^[1]	100 mg/kg	p.o.	/	210 μM·h
Rat^[1]	300 mg/kg	p.o.	/	780 μM·h
Rat^[1]	500 mg/kg	p.o.	/	1450 μM·h

Chemical Information

CAS No. 1219812-22-2
Molecular Weight 506.52
Formula C₂₆H₂₆N₄O₇
SMILES

C([C@@]1(C(=O)N(COC(C(C)(C)C)=O)C(=O)N1)C2=CC=3C(O2)=CC=CN3)N4C(=O)C=5C(C4)=CC=C(OC)C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tong L, et al. Development of a prodrug of hydantoin based TACE inhibitor. Bioorg Med Chem Lett. 2017;27(16):3704-3708. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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TACE-IN-1

All TNF Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TACE-IN-1 Related Classifications

HY-153504 Related Classifications