GSK-3β inhibitor 17
GSK-3β inhibitor 17 (compound 5 n) is a potent GSK-3β inhibitor. GSK-3β inhibitor 17 decreases cisplatin (HY-17394) induced p-p65, KIM-1 protein and mRNA expression. GSK-3β inhibitor 17 decreases cisplatin induced TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression. GSK-3β inhibitor 17 shows anti-inflammation effect and has the potential for the research of acute kidney injury.
For research use only. We do not sell to patients.
- CAS No.: 2521624-67-7
- Formula: C26H18F3N5O6S2
- Molecular Weight:617.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GSK-3β |
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Cell Line
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Type | Value | Description | References |
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| BV-2 | IC50 |
1.31 μM
Compound: 5n
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Anti-neuroinflammation in mouse BV2 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition measured after 24 hrs by Griess reagent based assay
Anti-neuroinflammation in mouse BV2 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hr followed by LPS addition measured after 24 hrs by Griess reagent based assay
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[PMID: 33017743] |
GSK-3β inhibitor 17 (compound 5 n) (16, 32, 64 µM) reduces cisplatin (HY-17394) induced p-p65, KIM-1 protein expression in a dose-dependent manner[1].
GSK-3β inhibitor 17 (32 µM) decreases the TNF-α, IL-1β, IL-6 and MCP-1 mRNA expression levels in cisplatin induces acute kidney injury (AKI) in HK-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HK-2 cells
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Concentration:16, 32, 64 µM
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Incubation Time:
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Result:Decreased the cisplatin (20 µM; 24 h) induced protein expression of p-p65, KIM-1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-8 weeks, 20-22 g, Male C57/BL6 mice (cisplatin 20 mg/kg i.p. for 3 days)[1]
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Dosage:12.5, 25, 50 mg/kg
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Administration:I.p.; 24 h before the modeling
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Result:Inhibited cisplatin-induced renal glycogen accumulation and tubular necrosis, 5n significantly reduced the protein level of p-P65 in cisplatin treatment, significantly downregulated mRNA levels of TNF-α, IL-1β, IL-6 and MCP-1.
Chemical Information
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CAS No. 2521624-67-7
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Molecular Weight 617.58
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Formula C26H18F3N5O6S2
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SMILES
COC(C1=CC=C(S1)S(=O)(NC2=CC=C(C=C2)C3=NC(C4=CC(NC5=CC=C(C=C5)OC(F)(F)F)=NC=C4)=NO3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK-3β inhibitor 17 Related Classifications
HY-163748 Related Classifications
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