2. Metabolic Enzyme/Protease Membrane Transporter/Ion Channel Cytoskeleton Stem Cell/Wnt TGF-beta/Smad
  3. Drug Metabolite Aquaporin Cadherin TGF-beta/Smad
  4. Aristolactam I

Aristolactam I  (Synonyms: Aristololactam; アリストロラクタムI; Aristolactam)

製品番号: HY-N2013 純度: 99.44%
COA 取扱説明書 Technical Support

Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis.

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Aristolactam I

Aristolactam I 構造式

CAS 番号 : 13395-02-3

容量 価格（税別） 在庫状況 数量
1 mg $70 在庫あり
5 mg $175 在庫あり
10 mg $280 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of Aristolactam I:

Aristolactam I 関連抗体

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製品説明

Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I can be isolated from Aristolochia plants. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I has anticancer activity against breast cancer. Aristolactam I is nephrotoxic. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis[1][2][3][4][5].

体外実験

Aristolactam I (0-40 μM; 21-48 h) inhibits cell migration and invasion through regulation of Twist1 in MDA-MB-231 breast cancer cells[1].
Aristolactam I (2.5-10 μM; 48 h) enhances the tendency of HK-2 cells to transform from epithelial cells to fibroblast-like cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aristolactam I 関連抗体

Real Time qPCR[1]

Cell Line: MDA-MB-231
Concentration: 0 μM, 40 μM
Incubation Time: 48 h
Result: Upregulated mRNA expression of CDH1 and downregulated CDH2 mRNA expression.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 0 μM, 20 μM, 40 μM
Incubation Time: 48 h
Result: Increased protein expression of E-cadherin, decreased N-cadherin and Twist1 protein expression.
体内実験

Aristolactam I (2.25-9 mg/kg; i.p.; 5 days) induces nephrotoxicity in Sprague-Dawley rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (weighing 200-250 g)[5]
Dosage: 2.25, 4.5, 9 mg/kg
Administration: Intraperitoneal injection, 5 days
Result: Significantly increased 24-hour urine volume.
Showed a stronger diuretic effect than Aristolochic acid I.
Caused early damage to the renal proximal tubules, with a stronger renal injury potential than Aristolochic acid I.
Inhibited the expression of renal AQP1, AQP2, and AQP4.
分子量

293.27

分子式

C17H11NO4
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC2=C(C3=C4C(C(OC)=CC=C4)=C2)C1=CC5=C3OCO5
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 12.5 mg/mL (42.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4098 mL 17.0491 mL 34.0983 mL
5 mM 0.6820 mL 3.4098 mL 6.8197 mL
10 mM 0.3410 mL 1.7049 mL 3.4098 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 99.44%

COA (258 KB) LCMS (164 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4098 mL 17.0491 mL 34.0983 mL 85.2457 mL
5 mM 0.6820 mL 3.4098 mL 6.8197 mL 17.0491 mL
10 mM 0.3410 mL 1.7049 mL 3.4098 mL 8.5246 mL
15 mM 0.2273 mL 1.1366 mL 2.2732 mL 5.6830 mL
20 mM 0.1705 mL 0.8525 mL 1.7049 mL 4.2623 mL
25 mM 0.1364 mL 0.6820 mL 1.3639 mL 3.4098 mL
30 mM 0.1137 mL 0.5683 mL 1.1366 mL 2.8415 mL
40 mM 0.0852 mL 0.4262 mL 0.8525 mL 2.1311 mL
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Aristolactam I Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aristolactam I13395-02-3Aristololactam AristolactamDrug MetaboliteAquaporinCadherinTGF-beta/SmadAQPTransforming growth factor betaSprague-DawleynephrotoxicityMDA-MB-231HK-2fibroblast-likeratsInhibitorinhibitorinhibit

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