2. Anti-infection
  3. Antibiotic Bacterial
  4. Azidocillin

Azidocillin, a semi-synthetic Penicillin, is an orally active β-lactam antibiotic. Azidocillin bears an azide functionality and retains on-target activity within bacteria. Azidocillin can be used to research osteitis caused by dental surgery, otitis media, enterococcal septicemia and other bacterial infectious diseases. Azidocillin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Azidocillin

Azidocillin Chemical Structure

CAS No. : 17243-38-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Other Forms of Azidocillin:

Azidocillin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Azidocillin, a semi-synthetic Penicillin, is an orally active β-lactam antibiotic. Azidocillin bears an azide functionality and retains on-target activity within bacteria. Azidocillin can be used to research osteitis caused by dental surgery, otitis media, enterococcal septicemia and other bacterial infectious diseases[1][2]. Azidocillin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

β-lactam

 

In Vitro

Azidocillin (0.004-16.0, >16.0 μg/mL; 24 h) inhibits the growth of most bacteria isolated from human mandibular osteitis, with mean MIC values ranging from 0.005 to 1.2 μg/mL across bacterial genera, and only a small subset of strains exhibiting MIC values above 2.0 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azidocillin Related Antibodies
In Vivo

Azidocillin (15 mg/kg; i.v.; single dose) administered intravenously to rats with bile fistulas and ligated renal pedicles results in 12.9% of the dose being excreted as biologically active drug in bile over 1 hour, with extensive biotransformation leading to low levels of active drug relative to total radioactivity excreted[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

375.40

Formula

C16H17N5O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](N=[N+]=[N-])C3=CC=CC=C3)=O)N1C2=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (266.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6638 mL 13.3191 mL 26.6383 mL
5 mM 0.5328 mL 2.6638 mL 5.3277 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6638 mL 13.3191 mL 26.6383 mL 66.5956 mL
5 mM 0.5328 mL 2.6638 mL 5.3277 mL 13.3191 mL
10 mM 0.2664 mL 1.3319 mL 2.6638 mL 6.6596 mL
15 mM 0.1776 mL 0.8879 mL 1.7759 mL 4.4397 mL
20 mM 0.1332 mL 0.6660 mL 1.3319 mL 3.3298 mL
25 mM 0.1066 mL 0.5328 mL 1.0655 mL 2.6638 mL
30 mM 0.0888 mL 0.4440 mL 0.8879 mL 2.2199 mL
40 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6649 mL
50 mM 0.0533 mL 0.2664 mL 0.5328 mL 1.3319 mL
60 mM 0.0444 mL 0.2220 mL 0.4440 mL 1.1099 mL
80 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8324 mL
100 mM 0.0266 mL 0.1332 mL 0.2664 mL 0.6660 mL
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Azidocillin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azidocillin17243-38-8AntibioticBacterialbiliary excretionpenicilloic acidratsdental alveolar serumbile fistulashuman plasma proteinmandibular osteitisrenal pediclesbacteriarat liver slicesInhibitorinhibitorinhibit

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