2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. BAY 2666605

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135).

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BAY 2666605

BAY 2666605 화학구조

CAS No. : 2275774-60-0

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

BAY 2666605 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135)[1].

IC50 & Target[1]

PDE3A

87 nM (IC50)

PDE3B

50 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
HeLa EC50
1.3 1
Compound: 39, BAY 2666605
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 37077378]
HeLa EC50
1.3 1
Compound: 39, BAY 2666605
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 37077378]
HeLa EC50
1.3 1
Compound: 39, BAY 2666605
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 37077378]
In Vitro

BAY 2666605 (example 135) has anticancer effects, potently inhibit? brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY 2666605 Related Antibodies
In Vivo

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
분자량

352.28

화학식

C17H12F4N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=C(C2=CC=C(C=C2)F)C=CC(C([C@@H](O3)C)=NNC3=O)=C1)F
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 250 mg/mL (709.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8387 mL 14.1933 mL 28.3865 mL
5 mM 0.5677 mL 2.8387 mL 5.6773 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.74%

SDS (251 KB)

COA (250 KB) HNMR (265 KB) LCMS (105 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8387 mL 14.1933 mL 28.3865 mL 70.9663 mL
5 mM 0.5677 mL 2.8387 mL 5.6773 mL 14.1933 mL
10 mM 0.2839 mL 1.4193 mL 2.8387 mL 7.0966 mL
15 mM 0.1892 mL 0.9462 mL 1.8924 mL 4.7311 mL
20 mM 0.1419 mL 0.7097 mL 1.4193 mL 3.5483 mL
25 mM 0.1135 mL 0.5677 mL 1.1355 mL 2.8387 mL
30 mM 0.0946 mL 0.4731 mL 0.9462 mL 2.3655 mL
40 mM 0.0710 mL 0.3548 mL 0.7097 mL 1.7742 mL
50 mM 0.0568 mL 0.2839 mL 0.5677 mL 1.4193 mL
60 mM 0.0473 mL 0.2366 mL 0.4731 mL 1.1828 mL
80 mM 0.0355 mL 0.1774 mL 0.3548 mL 0.8871 mL
100 mM 0.0284 mL 0.1419 mL 0.2839 mL 0.7097 mL
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BAY 2666605 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 26666052275774-60-0BAY2666605BAY-2666605Phosphodiesterase (PDE)PDE3A-SLFN12 Complexanticancer effectorally activeInhibitorinhibitorinhibit

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Inquiry Information

상품명:
BAY 2666605
Cat. No.:
HY-145924
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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