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BRM/BRG1 ATP Inhibitor-1 

Cat. No.: HY-119374 Purity: 98.49%
Handling Instructions

BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].

For research use only. We do not sell to patients.

BRM/BRG1 ATP Inhibitor-1 Chemical Structure

BRM/BRG1 ATP Inhibitor-1 Chemical Structure

CAS No. : 2270879-17-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 686 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].

IC50 & Target

IC50: ﹤0.005 µM (BRM, BRG1)[1]

Molecular Weight

318.27

Formula

C₁₁H₉F₃N₄O₂S

CAS No.

2270879-17-7

SMILES

FC1=CC(NC(NC2=CC(C(F)F)=NS2)=O)=C(CO)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (785.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1420 mL 15.7099 mL 31.4199 mL
5 mM 0.6284 mL 3.1420 mL 6.2840 mL
10 mM 0.3142 mL 1.5710 mL 3.1420 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BRM/BRG1 ATP Inhibitor-1OthersInhibitorinhibitorinhibit

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Product Name:
BRM/BRG1 ATP Inhibitor-1
Cat. No.:
HY-119374
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