2. GPCR/G Protein Metabolic Enzyme/Protease
  3. LPL Receptor Phosphodiesterase (PDE)
  4. BrP-LPA sodium

BrP-LPA sodium is a pan-opposite agent for lysophosphatidic acid (LPA). It has antagonistic activity against LPA1 (IC50 = 4520 nM), LPA2 (IC50 = 468 nM), LPA3, and LPA4. BrP-LPA sodium also has partial agonistic activity for LPA5, with its EC50 being 1282 nM. BrP-LPA sodium has ATX inhibitory activity. BrP-LPA sodium effectively inhibits the migration and invasion of breast cancer cells. BrP-LPA sodium achieves tumor regression and anti-angiogenesis in mice breast cancer xenograft model. BrP-LPA sodium can be used for the study of breast cancer.

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BrP-LPA sodium

BrP-LPA sodium Estructura química

No. CAS : 944265-88-7

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Other Forms of BrP-LPA sodium:

BrP-LPA sodium Related Antibodies

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Descripciòn

BrP-LPA sodium is a pan-opposite agent for lysophosphatidic acid (LPA). It has antagonistic activity against LPA1 (IC50 = 4520 nM), LPA2 (IC50 = 468 nM), LPA3, and LPA4. BrP-LPA sodium also has partial agonistic activity for LPA5, with its EC50 being 1282 nM. BrP-LPA sodium has ATX inhibitory activity. BrP-LPA sodium effectively inhibits the migration and invasion of breast cancer cells. BrP-LPA sodium achieves tumor regression and anti-angiogenesis in mice breast cancer xenograft model. BrP-LPA sodium can be used for the study of breast cancer[1].

IC50 & Target[1]

LPA1 Receptor

 

LPA2 Receptor

 

LPA3 Receptor

 

LPA5 Receptor

 

Autotaxin

 

Peso molecular

509.39

Fòrmula

C20H39BrNaO6P
No. CAS
SMILES

O=P(O)(O[Na])C(Br)C[C@H](O)COC(CCCCCCCCCCCCCCC)=O
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

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BrP-LPA sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BrP-LPA944265-88-7LPL ReceptorPhosphodiesterase (PDE)Lysophospholipid ReceptorLysophosphatidic acidLPA receptorautotaxinpan-antagonistinhibitorbreast cancercell migrationtumor regressionxenograftin vitroin vivoInhibitorinhibit

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Nombre del producto:
BrP-LPA sodium
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HY-148291
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