2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite Fatty Acid Synthase (FASN)
  4. Coenzyme A

Coenzyme A  (Synonyms: CoA; コエンザイムA; 補酵素A)

製品番号: HY-128851 純度: 96.81%
COA 取扱説明書 Technical Support

Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 85-61-0

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
5 mg $50 在庫あり
10 mg $60 在庫あり
25 mg $110 在庫あり
50 mg $195 在庫あり
100 mg $340 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Other Forms of Coenzyme A:

Coenzyme A 関連抗体

Top Publications Citing Use of Products

    Coenzyme A purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715.  [Abstract]

    CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. Immunoblots detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice.

    Coenzyme A purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715.  [Abstract]

    CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC detection for HMGCS2 in small intestinal crypts from control and CoA-treated mice. Scale bar, 20 µm.

    Coenzyme A purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715.  [Abstract]

    Flow cytometry and quantification of IL-22 expression in CD8αβ+ cells after 24 h of CoA (500 µM) treatment (n = 8 per group).

    Coenzyme A purchased from MedChemExpress. Usage Cited in: Nature. 2025 Nov;647(8090):706-715.  [Abstract]

    CoA was provided through the drinking water at 500 mg/L and i.p. injection (50 mg/kg) three times per week for 30 days. IHC for regenerating crypts using OLFM4 as a stem cell marker in control and CoA-treated mice.

    Coenzyme A purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8.  [Abstract]

    phosphorylation level of PI3K, AKT and ERK in HT29 cells treated with TNF-α/IFN-γ combined with 250 µM CoA.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1].

    体外実験

    Coenzyme A functions to generate metabolically active thioesters, while it also has the potential to act as a low-molecular-weight antioxidant in response to oxidative and metabolic stress in exponentially growing bacteria[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Coenzyme A 関連抗体
    分子量

    767.53

    分子式

    C21H36N7O16P3S
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CC([C@H](C(NCCC(NCCS)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O)=O)(O)=O)(O)=O
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (130.29 mM; ultrasonic and warming and heat to 60°C)

    DMSO : 100 mg/mL (130.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3029 mL 6.5144 mL 13.0288 mL
    5 mM 0.2606 mL 1.3029 mL 2.6058 mL
    10 mM 0.1303 mL 0.6514 mL 1.3029 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1.63 mg/mL (2.12 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.63 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 1.63 mg/mL (2.12 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.63 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 25 mg/mL (32.57 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: ≥97.0%

    COA (248 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.3029 mL 6.5144 mL 13.0288 mL 32.5720 mL
    5 mM 0.2606 mL 1.3029 mL 2.6058 mL 6.5144 mL
    10 mM 0.1303 mL 0.6514 mL 1.3029 mL 3.2572 mL
    15 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1715 mL
    20 mM 0.0651 mL 0.3257 mL 0.6514 mL 1.6286 mL
    25 mM 0.0521 mL 0.2606 mL 0.5212 mL 1.3029 mL
    30 mM 0.0434 mL 0.2171 mL 0.4343 mL 1.0857 mL
    40 mM 0.0326 mL 0.1629 mL 0.3257 mL 0.8143 mL
    50 mM 0.0261 mL 0.1303 mL 0.2606 mL 0.6514 mL
    60 mM 0.0217 mL 0.1086 mL 0.2171 mL 0.5429 mL
    80 mM 0.0163 mL 0.0814 mL 0.1629 mL 0.4072 mL
    100 mM 0.0130 mL 0.0651 mL 0.1303 mL 0.3257 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Coenzyme A Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Coenzyme A85-61-0Endogenous MetaboliteFatty Acid Synthase (FASN)ubiquitous essential cofactoracyl group carriercitric acid cyclefatty acid metabolismmetabolismInhibitorinhibitorinhibit

    最近チェックした製品:

    オンラインお問い合わせ

    Your information is safe with us. * Required Fields.

    製品名

    		  

    カスタマ需要量 *

    お名前 *

    		 

    タイトル

    メールアドレス *

    		 

    電話番号 *

    デパートメント

    		 

    組纖名 *

    市区町村

    都道府県

    国或いは地域 *

    		      

    必ず会社名を記載ください。個人への返信は行いません。

    備考

    バルクお問い合わせ

    Inquiry Information

    製品名:
    Coenzyme A
    製品番号:
    HY-128851
    数量:
    MCE 日本正規代理店:

    カスタマーレビュー

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    製品名

    		  

    Lot #

    お名前 *

    		 

    メールアドレス *

    電話番号 *

    		 

    部門 *

    組纖名 *

    		 

    国或いは地域 *

    備考

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.