2. Anti-infection
  3. Beta-lactamase Bacterial Antibiotic
  4. Dicloxacillin

Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus.

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Dicloxacillin

Dicloxacillin 構造式

CAS 番号 : 3116-76-5

容量 価格（税別） 在庫状況 数量
5 mg $65 お問い合わせ 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
10 mg $105 お問い合わせ 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
25 mg $210 お問い合わせ 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 mg $335 お問い合わせ 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 mg $540 お問い合わせ 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
200 mg   お問い合わせ  
500 mg   お問い合わせ  
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Based on 3 publication(s) in Google Scholar

Other Forms of Dicloxacillin:

Dicloxacillin 関連抗体

Top Publications Citing Use of Products

Beta-lactamase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

Antibiotic アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[1].

IC50 & Target

β-lactam

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
16.6 3
Compound: Dicloxacillin
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
[PMID: 23344796]
CHO IC50
16.6 3
Compound: Dicloxacillin
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
[PMID: 23344796]
THP-1 EC50
0.04 10
Compound: DCX
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
[PMID: 20308386]
Sf21 IC50
69.7 3
Compound: Dicloxacillin
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
THP-1 EC50
0.31 10
Compound: DCX
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
[PMID: 20308386]
Sf21 IC50
111.1 3
Compound: Dicloxacillin
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
Sf21 IC50
111.1 3
Compound: Dicloxacillin
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
THP-1 EC50
0.04 10
Compound: DCX
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
[PMID: 20308386]
Sf21 IC50
69.7 3
Compound: Dicloxacillin
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake
[PMID: 21965623]
THP-1 EC50
0.31 10
Compound: DCX
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
[PMID: 20308386]
THP-1 EC50
0.04 10
Compound: DCX
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs
[PMID: 20308386]
THP-1 EC50
0.31 10
Compound: DCX
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs
[PMID: 20308386]
体外実験

Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dicloxacillin 関連抗体
体内実験

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)[3].
Dosage: 125 mg/kg.
Administration: IV injection, single doses.
Result: All the mice survived.
臨床実験
分子量

470.33

分子式

C19H17Cl2N3O5S
CAS 番号
SMILES

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)N1C2=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Dicloxacillin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dicloxacillin3116-76-5Beta-lactamaseBacterialAntibioticβ-lactamaseβ-lactam antibioticpenicillinInhibitorinhibitorinhibit

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製品名:
Dicloxacillin
製品番号:
HY-B1459A
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