1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Dicloxacillin Sodium hydrate

Dicloxacillin Sodium hydrate (Synonyms: Dicloxacillin sodium salt monohydrate)

Cat. No.: HY-B0977 Purity: ≥98.0%
Handling Instructions

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus.

For research use only. We do not sell to patients.

Dicloxacillin Sodium hydrate Chemical Structure

Dicloxacillin Sodium hydrate Chemical Structure

CAS No. : 13412-64-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus[1][2][3].

In Vitro

Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Strains ATCC 25923 and E19977.
Concentration: 0-500 mg/L.
Incubation Time: Up to 24 h.
Result: Exhibited EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively.
In Vivo

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)[4].
Dosage: 125 mg/kg.
Administration: IV injection, single doses.
Result: All the mice survived.
Clinical Trial
Molecular Weight

510.32

Formula

C₁₉H₁₈Cl₂N₃NaO₆S

CAS No.
SMILES

O=C(O[Na])[[email protected]@H](C(C)(C)S[[email protected]]1([H])[[email protected]@H]2NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)N1C2=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (48.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9596 mL 9.7978 mL 19.5955 mL
5 mM 0.3919 mL 1.9596 mL 3.9191 mL
10 mM 0.1960 mL 0.9798 mL 1.9596 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.94%

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Keywords:

Dicloxacillin SodiumDicloxacillin sodium saltBacterialAntibioticperitonitissepsisInhibitorinhibitorinhibit

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Dicloxacillin Sodium hydrate
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