Dicloxacillin

Name: Dicloxacillin
Brand: MedChemExpress
SKU: HY-B1459A
Rating: 5.0 (3 reviews)

Cat. No.: HY-B1459A: Data Sheet Handling Instructions
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Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus.

For research use only. We do not sell to patients.

Dicloxacillin Chemical Structure

CAS No. : 3116-76-5

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5 mg	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
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200 mg	Get quote
500 mg	Get quote

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Based on 3 publication(s) in Google Scholar

Other Forms of Dicloxacillin:

3 Publications Citing Use of MCE Dicloxacillin

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

β-lactam

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	16.6 μM Compound: Dicloxacillin	Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins	[PMID: 23344796]
Sf21	IC₅₀	111.1 μM Compound: Dicloxacillin	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	69.7 μM Compound: Dicloxacillin	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
THP-1	EC₅₀	0.04 mg/L Compound: DCX	Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs Antimicrobial activity against Staphylococcus aureus ATCC 25923 infected in human THP-1 cells after 24 hrs	[PMID: 20308386]
THP-1	EC₅₀	0.31 mg/L Compound: DCX	Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs Antimicrobial activity against Staphylococcus aureus E19977 infected in human THP-1 cells after 24 hrs	[PMID: 20308386]

In Vitro

Dicloxacillin exhibits EC₅₀ values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female outbred Swiss Webster mice (Murine peritonitis-sepsis model)^[3].
Dosage:	125 mg/kg.
Administration:	IV injection, single doses.
Result:	All the mice survived.

Clinical Trial

Molecular Weight

470.33

Formula

C₁₉H₁₇Cl₂N₃O₅S

CAS No.

3116-76-5

SMILES

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=C(Cl)C=CC=C4Cl)=O)N1C2=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25. [Content Brief]

[2]. Anne Sandberg, et al. Intra- and extracellular activities of dicloxacillin against Staphylococcus aureus in vivo and in vitro. Antimicrob Agents Chemother. 2010 Jun;54(6):2391-400. [Content Brief]

[3]. John Chu, et al. Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat Chem Biol. 2016 Dec;12(12):1004-1006. [Content Brief]

Dicloxacillin Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dicloxacillin3116-76-5Beta-lactamaseBacterialAntibioticβ-lactamaseβ-lactam antibioticpenicillinInhibitorinhibitorinhibit

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Dicloxacillin

Customer Review

Other Forms of Dicloxacillin:

Dicloxacillin Related Antibodies

3 Publications Citing Use of MCE Dicloxacillin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Beta-lactamase Isoform Specific Products:

View All Antibiotic Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Dicloxacillin Related Antibodies

Dicloxacillin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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