2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. DNQX disodium salt

DNQX disodium salt  (Synonyms: FG 9041 disodium salt)

Cat. No.: HY-103233 Pureza: 98.07%
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Instrucciones de manejo Technical Support

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively).

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DNQX disodium salt

DNQX disodium salt Estructura química

No. CAS : 1312992-24-7

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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Revisión del cliente

Based on 11 publication(s) in Google Scholar

Other Forms of DNQX disodium salt:

DNQX disodium salt Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas iGluR:

Ver todas las isoformas
AMPA Receptor NMDA Receptor Kainate Receptor

  • Actividad biológica

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Descripciòn

DNQX (FG 9041) disodium salt, a quinoxaline derivative, is a selective, potent competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5, 2 and 40 μM for AMPA, kainate and NMDA receptors, respectively)[1].

IC50 & Target

AMPA Receptor

 

Kainate Receptor

 

In Vitro

DNQX (FG 9041) disodium salt selectively depolarizes thalamic reticular nucleus (TRN) neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DNQX disodium salt Related Antibodies
In Vivo

DNQX (FG 9041), a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

296.10

Fòrmula

C8H2N4Na2O6
No. CAS
Appearance

Solid

Color

Pink to red

SMILES

[O-][N+](C1=CC(N=C2O[Na])=C(C=C1[N+]([O-])=O)N=C2O[Na])=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (168.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 3.33 mg/mL (11.25 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3772 mL 16.8862 mL 33.7724 mL
5 mM 0.6754 mL 3.3772 mL 6.7545 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.3772 mL 16.8862 mL 33.7724 mL 84.4309 mL
5 mM 0.6754 mL 3.3772 mL 6.7545 mL 16.8862 mL
10 mM 0.3377 mL 1.6886 mL 3.3772 mL 8.4431 mL
DMSO 15 mM 0.2251 mL 1.1257 mL 2.2515 mL 5.6287 mL
20 mM 0.1689 mL 0.8443 mL 1.6886 mL 4.2215 mL
25 mM 0.1351 mL 0.6754 mL 1.3509 mL 3.3772 mL
30 mM 0.1126 mL 0.5629 mL 1.1257 mL 2.8144 mL
40 mM 0.0844 mL 0.4222 mL 0.8443 mL 2.1108 mL
50 mM 0.0675 mL 0.3377 mL 0.6754 mL 1.6886 mL
60 mM 0.0563 mL 0.2814 mL 0.5629 mL 1.4072 mL
80 mM 0.0422 mL 0.2111 mL 0.4222 mL 1.0554 mL
100 mM 0.0338 mL 0.1689 mL 0.3377 mL 0.8443 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DNQX disodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DNQX disodium1312992-24-7FG 9041 disodiumiGluRIonotropic glutamate receptorscompetitiveselectivenon-NMDAthalamicreticularnucleusquinoxalineInhibitorinhibitorinhibit

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Nombre del producto:
DNQX disodium salt
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HY-103233
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