2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Ethotoin

Ethotoin (Peganone) is an orally active anticonvulsant agent used in epilepsy research, Ethotoin is a hydantoin, similar to phenytoin.

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Ethotoin

Ethotoin Chemische Struktur

CAS. Nr. : 86-35-1

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Based on 2 publication(s) in Google Scholar

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Ethotoin Related Antibodies

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Beschreibung

Ethotoin (Peganone) is an orally active anticonvulsant agent used in epilepsy research, Ethotoin is a hydantoin, similar to phenytoin[1].

In Vivo

Ethotoin (oral gavage; 600 mg/kg; once) results in mild mortality and weight loss of offspring, after dosing on gestational day 18[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant Sprague-Dawley CD rats[2]
Dosage: 600 mg/kg
Administration: Oral gavage; 600 mg/kg; once
Result: Preweaning mortality for Ethotoin was 2.0%, Ethotoin -exposed animals weighed approximately 6.6% less than controls.
Molekulargewicht

204.23

Formel

C11H12N2O2
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CC)C(C(C2=CC=CC=C2)N1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : ≥ 100 mg/mL (489.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8965 mL 24.4823 mL 48.9646 mL
5 mM 0.9793 mL 4.8965 mL 9.7929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8965 mL 24.4823 mL 48.9646 mL 122.4116 mL
5 mM 0.9793 mL 4.8965 mL 9.7929 mL 24.4823 mL
10 mM 0.4896 mL 2.4482 mL 4.8965 mL 12.2412 mL
15 mM 0.3264 mL 1.6322 mL 3.2643 mL 8.1608 mL
20 mM 0.2448 mL 1.2241 mL 2.4482 mL 6.1206 mL
25 mM 0.1959 mL 0.9793 mL 1.9586 mL 4.8965 mL
30 mM 0.1632 mL 0.8161 mL 1.6322 mL 4.0804 mL
40 mM 0.1224 mL 0.6121 mL 1.2241 mL 3.0603 mL
50 mM 0.0979 mL 0.4896 mL 0.9793 mL 2.4482 mL
60 mM 0.0816 mL 0.4080 mL 0.8161 mL 2.0402 mL
80 mM 0.0612 mL 0.3060 mL 0.6121 mL 1.5301 mL
100 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
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Ethotoin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethotoin86-35-1PeganoneSodium ChannelNa channelsNa+ channelsanticonvulsantepilepsyhydantoinInhibitorinhibitorinhibit

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