Glycerophosphocholine (Synonyms: (S)-Glycerolphosphocholine)

Cat. No.: HY-W096638A Pureza: 98.89%: Ficha de datos
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Glycerophosphocholine ((S)-Glycerolphosphocholine) is an orally active metabolite that crosses the blood-brain barrier. Glycerophosphocholine acts as a precursor of acetylcholine, a specific marker for phosphatidylcholine breakdown, a major water-soluble storage form of choline, and an intermediate in phosphatidylcholine metabolism. Glycerophosphocholine is specifically elevated in the cerebrospinal fluid of Alzheimer's disease models, and it also promotes growth hormone secretion and fat oxidation. Glycerophosphocholine is also a potential biomarker for breast cancer.

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Glycerophosphocholine Estructura química

No. CAS : 4217-84-9

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	Obtener un presupuesto
50 mg	Obtener un presupuesto

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Other Forms of Glycerophosphocholine:

Glycerylphosphorylcholine Obtener un presupuesto

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Human Endogenous Metabolite Microbial Metabolite

Actividad biológica
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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
Vero C1008	IC₅₀	>2.0 × 10⁵ 41 Compound: COVC-3370941208	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	10.6019/CHEMBL4651402

In Vitro

Glycerophosphocholine can be hydrolyzed to choline by GPCPD1 both inside and outside Caco-2 cells, thereby regulating choline homeostasis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Glycerophosphocholine (500 mg/kg; oral gavage; single dose) increases circulating choline, betaine, and TMAO levels in healthy 6-week-old male C57BL/6J mice, with peak TMAO elevation occurring 3 to 6 hours post-dose^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J (6-week-old, male)^[1]
Dosage:	500 mg/kg
Administration:	oral gavage; single dose
Result:	Increased blood glycerophosphocholine (GPC) and choline concentrations rapidly at 0.5 hours post-administration. Increased blood trimethylamine N-oxide (TMAO) levels at 3 and 6 hours post-administration. Increased blood betaine concentrations at 3 and 6 hours post-administration.

Peso molecular

257.22

Fòrmula

C₈H₂₀NO₆P

No. CAS

4217-84-9

Appearance

Solid

Color

White to off-white

SMILES

C[N+](C)(CCOP([O-])(OC[C@H](CO)O)=O)C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

H₂O : 2.5 mg/mL (9.72 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8877 mL	19.4386 mL	38.8772 mL
5 mM	0.7775 mL	3.8877 mL	7.7754 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 98.89%

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Ficha de datos (271 KB) SDS (393 KB)

COA (244 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen S, et al. Role of Gpcpd1 in intestinal alpha-glycerophosphocholine metabolism and trimethylamine N-oxide production. J Biol Chem. 2024;300(12):107965. [Content Brief]

[2]. Moestue SA, et al. Glycerophosphocholine (GPC) is a poorly understood biomarker in breast cancer. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2506; author reply E2507. [Content Brief]

[3]. Kawamura T, et al. Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults. Nutrition. 2012;28(11-12):1122-1126. [Content Brief]

[4]. Walter A, et al. Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8877 mL	19.4386 mL	38.8772 mL	97.1931 mL
H₂O	5 mM	0.7775 mL	3.8877 mL	7.7754 mL	19.4386 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Glycerophosphocholine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycerophosphocholine4217-84-9(S)-GlycerolphosphocholineEndogenous Metaboliteatherosclerosiscerebrospinal fluidC57BL/6J miceGlycerophosphodiesterase 1Alzheimer’s diseaseneurodegenerative disordershippocampal acetylcholineCaco-2 cell monolayersstrokebreast cancerInhibitorinhibitorinhibit

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