GSK-3β inhibitor 10

製品番号: HY-147134 純度: 98.04%: Data Sheet SDS COA 取扱説明書
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GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC₅₀ value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

GSK-3β inhibitor 10 構造式

CAS 番号 : 1198098-03-1

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 132	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 132	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$120	在庫あり	Estimated Time of Arrival: December 31
10 mg	$195	在庫あり	Estimated Time of Arrival: December 31
25 mg	$390	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

GSK-3 アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

GSK-3 GSK-3α GSK-3β

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

GSK-3β inhibitor 10 (compound 14a) is a highly potent GSK-3β inhibitor with an IC₅₀ value of 80.5 nM. GSK-3β inhibitor 10 can be used for researching Alzheimer’s disease^[1].

IC₅₀ & Target^[1]

GSK-3β

80.5 nM (IC₅₀)

分子量

264.30

分子式

C₁₂H₁₂N₂O₃S

CAS 番号

1198098-03-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC(C=C1/C=C2C(N=C(S/2)N)=O)=C(C=C1)OC

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (94.59 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7836 mL	18.9179 mL	37.8358 mL
5 mM	0.7567 mL	3.7836 mL	7.5672 mL
10 mM	0.3784 mL	1.8918 mL	3.7836 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.04%

Select Batch:

データシート (273 KB) SDS (393 KB)

COA (251 KB) HNMR (138 KB) LCMS (88 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Arfeen M, et al. Design, synthesis and biological evaluation of 5-benzylidene-2-iminothiazolidin-4-ones as selective GSK-3β inhibitors. Eur J Med Chem. 2016 Oct 4;121:727-736. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7836 mL	18.9179 mL	37.8358 mL	94.5895 mL
	5 mM	0.7567 mL	3.7836 mL	7.5672 mL	18.9179 mL
	10 mM	0.3784 mL	1.8918 mL	3.7836 mL	9.4589 mL
	15 mM	0.2522 mL	1.2612 mL	2.5224 mL	6.3060 mL
	20 mM	0.1892 mL	0.9459 mL	1.8918 mL	4.7295 mL
	25 mM	0.1513 mL	0.7567 mL	1.5134 mL	3.7836 mL
	30 mM	0.1261 mL	0.6306 mL	1.2612 mL	3.1530 mL
	40 mM	0.0946 mL	0.4729 mL	0.9459 mL	2.3647 mL
	50 mM	0.0757 mL	0.3784 mL	0.7567 mL	1.8918 mL
	60 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5765 mL
	80 mM	0.0473 mL	0.2365 mL	0.4729 mL	1.1824 mL