1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. iGluR
    Cytochrome P450
  3. GYKI-47261 dihydrochloride

GYKI-47261 dihydrochloride 

Cat. No.: HY-19435A
Handling Instructions

GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1.

For research use only. We do not sell to patients.

GYKI-47261 dihydrochloride Chemical Structure

GYKI-47261 dihydrochloride Chemical Structure

CAS No. : 1217049-32-5

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Description

GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC50 of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1[1][2].

In Vivo

GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice[1].
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP[1].

Animal Model: Male C57 black mice, weighing 23-30 g[1]
Dosage: 20 mg/kg
Administration: I.p.
Result: Reversed the MPTP-induced decrease in striatal concentrations.
Molecular Weight

395.71

Formula

C₁₈H₁₇Cl₃N₄

CAS No.

1217049-32-5

SMILES

NC1=CC=C(C2=NN3C(CC4=CC=C(Cl)C=C42)=NC(C)=C3)C=C1.[H]Cl.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GYKI-47261GYKI47261GYKI 47261iGluRCytochrome P450Ionotropic glutamate receptorsCYPsneurotoxicityParkinsonsdiseaseantiischemiceanticonvulsivecompetitiveInhibitorinhibitorinhibit

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GYKI-47261 dihydrochloride
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HY-19435A
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