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Cat. No.: HY-19435A

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GYKI-47261 dihydrochloride

Name: GYKI-47261 dihydrochloride
Brand: MedChemExpress
SKU: HY-19435A
Price: 544.00 USD
Availability: InStock
Rating: 5 (1 reviews)

GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC₅₀ of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1.

For research use only. We do not sell to patients.

CAS No.: 1217049-32-5
Formula: C₁₈H₁₇Cl₃N₄
Molecular Weight:395.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

GYKI-47261 dihydrochloride Chemical Structure

CAS No.: 1217049-32-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
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Biological Activity

Description

All iGluR Isoforms :

All Cytochrome P450 Isoforms :

In Vivo

GYKI-47261 dihydrochloride (6 mg/kg; i.v.) shows antiischemice effect in a transient focal ischemia model, in rats. GYKI-47261 dihydrochloride (p.o.) potently mitigated the tremor induced by oxotremorine with ED50 of 16.8 mg/kg in male CD1 mice^[1].
GYKI-47261 dihydrochloride(20 mg/kg; i.p.) reverses the dopamine depleting effect of MPTP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57 black mice, weighing 23-30 g^[1]
Dosage:

20 mg/kg
Administration:

I.p.
Result:

Reversed the MPTP-induced decrease in striatal concentrations.

Chemical Information

CAS No. 1217049-32-5
Molecular Weight 395.71
Formula C₁₈H₁₇Cl₃N₄
SMILES

NC1=CC=C(C2=NN3C(CC4=CC=C(Cl)C=C42)=NC(C)=C3)C=C1.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abrahám G, et al. New non competitive AMPA antagonists. Bioorg Med Chem. 2000;8(8):2127-2143. [Content Brief]

[2]. Tamási V, et al. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer. Drug Metab Dispos. 2003;31(11):1310-1314. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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GYKI-47261 dihydrochloride

Cyclothiazide

(S)-AMPA

Talampanel

CX516

CP-465022

Omberacetam

CNQX

NBQX

Cyclothiazide (Standard)

NBQX disodium

CNQX disodium

CX546

All iGluR Isoforms

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

GYKI-47261 dihydrochloride

Cyclothiazide

(S)-AMPA

Talampanel

CX516

CP-465022

Omberacetam

CNQX

NBQX

Cyclothiazide (Standard)

NBQX disodium

CNQX disodium

CX546

All iGluR Isoforms

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

GYKI-47261 dihydrochloride Related Classifications

HY-19435A Related Classifications

Bioz