2. Apoptosis Epigenetics
  3. Apoptosis MicroRNA
  4. Gypenoside LI

Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration.

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Gypenoside LI Chemical Structure

Gypenoside LI Chemical Structure

CAS No. : 94987-10-7

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Based on 1 publication(s) in Google Scholar

Gypenoside LI Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration[1][2].

In Vitro

Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells[1].
Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells[1].
Gypenoside LI could obviously suppress the expression of CDK1 protein rather than CDK2 and CDK4 proteins[1].
Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells[2].
Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway[2].
Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gypenoside LI Related Antibodies

Cell Viability Assay[1]

Cell Line: A549 cells.
Concentration: 0-80 μM.
Incubation Time: 24 h.
Result: Displayed the strongest activity with the IC50 values of 21.36 ± 0.78 μM.
Molecular Weight

801.01

Formula

C42H72O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H]([C@@H](C4)O)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CC/C=C(C)\C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (124.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2484 mL 6.2421 mL 12.4842 mL
5 mM 0.2497 mL 1.2484 mL 2.4968 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.29%

COA (253 KB) HNMR (133 KB) CNMR (157 KB) RP-HPLC (429 KB) MS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2484 mL 6.2421 mL 12.4842 mL 31.2106 mL
5 mM 0.2497 mL 1.2484 mL 2.4968 mL 6.2421 mL
10 mM 0.1248 mL 0.6242 mL 1.2484 mL 3.1211 mL
15 mM 0.0832 mL 0.4161 mL 0.8323 mL 2.0807 mL
20 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.5605 mL
25 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2484 mL
30 mM 0.0416 mL 0.2081 mL 0.4161 mL 1.0404 mL
40 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7803 mL
50 mM 0.0250 mL 0.1248 mL 0.2497 mL 0.6242 mL
60 mM 0.0208 mL 0.1040 mL 0.2081 mL 0.5202 mL
80 mM 0.0156 mL 0.0780 mL 0.1561 mL 0.3901 mL
100 mM 0.0125 mL 0.0624 mL 0.1248 mL 0.3121 mL
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Gypenoside LI Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gypenoside LI94987-10-7ApoptosisMicroRNAmiRNAmelanomabreastcancerA459NSCLCInhibitorinhibitorinhibit

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