Gypenoside LI
Based on 1 publication(s) in Google Scholar
Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration.
For research use only. We do not sell to patients.
- Purity: 98.29%
- CAS No.: 94987-10-7
- Formula: C42H72O14
- Molecular Weight:801.01
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Gypenoside LI
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
50.96 μg/mL
Compound: 4
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
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[PMID: 24321343] |
| A549 | IC50 |
91 μg/mL
Compound: Gypenoside LI
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Cytotoxicity against human A549 cells assessed as decrease in viable cells after 48 hrs by CCK-8 assay
Cytotoxicity against human A549 cells assessed as decrease in viable cells after 48 hrs by CCK-8 assay
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[PMID: 26922140] |
Gypenoside LI (0-80 μM) inhibits A549 cells in a dose-dependent manner. Gypenoside LI induces G2/M and arrest apoptosis in A549 cells[1].
Gypenoside LI increases intracellular ROS level. Gypenoside LI suppressed migration of A549 cells[1].
Gypenoside LI could obviously suppress the expression of CDK1 protein rather than
CDK2 and CDK4 proteins[1].
Gypenoside LI inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells[2].
Gypenoside LI (75 and 29.71 μg/mL) can induce intrinsic apoptosis along with S phase arrest. Gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway[2].
Gypenoside LI induces PARP cleavage, increased the expression of cleaved caspase-9 and BID death agonist, and downregulates the expression of FLIP (long form) and BCl-2 in the A375 and SK-MEL-28 melanoma cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells.
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Concentration:0-80 μM.
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Incubation Time:24 h.
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Result:Displayed the strongest activity with the IC50 values of 21.36 ± 0.78 μM.
Chemical Information
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CAS No. 94987-10-7
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Appearance Solid
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Molecular Weight 801.01
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Formula C42H72O14
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Color White to off-white
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SMILES
C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H]([C@@H](C4)O)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CC/C=C(C)\C)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
Inhibitory Effects of Heat-Processed Gynostemma pentaphyllum Extract (Actiponin®) and Its Components on Cartilage Breakdown in Osteoarthritis. [Abstract]2025 Feb 18;26(4):1728. PMID: 40004191
Solvent & Solubility
DMSO : 100 mg/mL (124.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Shao-Fang Xing, et al. The inhibitory effect of gypenoside stereoisomers, gypenoside L and gypenoside LI, isolated from Gynostemma pentaphyllum on the growth of human lung cancer A549 cells. J Ethnopharmacol. 2018 Jun 12;219:161-172. [Content Brief]
[2]. Ma-Li Zu, et al. Monomer gypenoside LI from Gynostemma pentaphyllum inhibits cell proliferation and upregulates expression of miR-128-3p in melanoma cells. J Biochem Mol Toxicol. 2020 May;34(5):e22460. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2484 mL | 6.2421 mL | 12.4842 mL | 31.2106 mL |
| 5 mM | 0.2497 mL | 1.2484 mL | 2.4968 mL | 6.2421 mL | |
| 10 mM | 0.1248 mL | 0.6242 mL | 1.2484 mL | 3.1211 mL | |
| 15 mM | 0.0832 mL | 0.4161 mL | 0.8323 mL | 2.0807 mL | |
| 20 mM | 0.0624 mL | 0.3121 mL | 0.6242 mL | 1.5605 mL | |
| 25 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2484 mL | |
| 30 mM | 0.0416 mL | 0.2081 mL | 0.4161 mL | 1.0404 mL | |
| 40 mM | 0.0312 mL | 0.1561 mL | 0.3121 mL | 0.7803 mL | |
| 50 mM | 0.0250 mL | 0.1248 mL | 0.2497 mL | 0.6242 mL | |
| 60 mM | 0.0208 mL | 0.1040 mL | 0.2081 mL | 0.5202 mL | |
| 80 mM | 0.0156 mL | 0.0780 mL | 0.1561 mL | 0.3901 mL | |
| 100 mM | 0.0125 mL | 0.0624 mL | 0.1248 mL | 0.3121 mL |
Gypenoside LI Related Classifications
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