2. Anti-infection Immunology/Inflammation
  3. HIV HCV HPV Influenza Virus Interleukin Related
  4. HEP-1

HEP-1  (Synonyms: Human ezrin peptide (324-337))

製品番号: HY-P10056 純度: 99.88%
COA 取扱説明書 Technical Support

HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases.

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HEP-1

HEP-1 構造式

CAS 番号 : 174641-44-2

容量 価格（税別） 在庫状況 数量
5 mg $65 在庫あり
10 mg $105 在庫あり
25 mg $210 在庫あり
50 mg $336 在庫あり
100 mg $538 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 0 publication(s) in Google Scholar

HEP-1 関連抗体

Top Publications Citing Use of Products

HIV アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
HIV HIV-1 HIV-2

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases[1][2].

体内実験

HEP-1 (2.25 mg/kg; intraperitoneal injection; once every two days; from day 1 to day 19) has a protective effect in the DSS (HY-116282C)-induced murine ulcerative colitis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight to ten weeks old male C57BL/6 mice (21-23 g) treated DSS (HY-116282C)[1]
Dosage: 2.25 mg/kg
Administration: Intraperitoneal injection (i.p.); once every two days; from day 1 to day 19
Result: Significantly reduced the body weight loss, DAI score, and mortality rate of the mice.
Inhibited the elevated expression of pro-inflammatory cytokines (such as IL-1β, IL-6, and Nos2) in colon tissues.
significantly reduced the accumulation of Ly6G+ granulocytes and Ly6C+ monocytes in the colon infiltrate.
Prevented the shortening of the colon caused by DSS colitis.
臨床実験
分子量

1818.00

分子式

C74H132N26O27
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu
Sequence Shortening

TEKKRRETVEREKE
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : ≥ 50 mg/mL (27.50 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5501 mL 2.7503 mL 5.5006 mL
5 mM 0.1100 mL 0.5501 mL 1.1001 mL
10 mM 0.0550 mL 0.2750 mL 0.5501 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.88%

COA (249 KB) RP-HPLC (267 KB) MS (72 KB) Elemental Analysis Report (107 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5501 mL 2.7503 mL 5.5006 mL 13.7514 mL
5 mM 0.1100 mL 0.5501 mL 1.1001 mL 2.7503 mL
10 mM 0.0550 mL 0.2750 mL 0.5501 mL 1.3751 mL
15 mM 0.0367 mL 0.1834 mL 0.3667 mL 0.9168 mL
20 mM 0.0275 mL 0.1375 mL 0.2750 mL 0.6876 mL
25 mM 0.0220 mL 0.1100 mL 0.2200 mL 0.5501 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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HEP-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HEP-1174641-44-2Human ezrin peptide (324-337)HEP1HEP 1HIVHCVHPVInfluenza VirusInterleukin RelatedHuman immunodeficiency virusHepatitis C virusHuman papillomavirusILinfectioncolitis modelInhibitorinhibitorinhibit

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