2. Anti-infection Immunology/Inflammation
  3. HIV HCV HPV Influenza Virus Interleukin Related
  4. HEP-1

HEP-1  (Synonyms: Human ezrin peptide (324-337))

Cat. No.: HY-P10056 Pureté: 99.88%
COA
SDS
Instruction de manipulation Technical Support

HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases.

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Synthèse de peptides personnalisée

HEP-1

HEP-1 Chemical Structure

CAS No. : 174641-44-2

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HEP-1 Related Antibodies

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases[1][2].

In Vivo

HEP-1 (2.25 mg/kg; intraperitoneal injection; once every two days; from day 1 to day 19) has a protective effect in the DSS (HY-116282C)-induced murine ulcerative colitis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight to ten weeks old male C57BL/6 mice (21-23 g) treated DSS (HY-116282C)[1]
Dosage: 2.25 mg/kg
Administration: Intraperitoneal injection (i.p.); once every two days; from day 1 to day 19
Result: Significantly reduced the body weight loss, DAI score, and mortality rate of the mice.
Inhibited the elevated expression of pro-inflammatory cytokines (such as IL-1β, IL-6, and Nos2) in colon tissues.
significantly reduced the accumulation of Ly6G+ granulocytes and Ly6C+ monocytes in the colon infiltrate.
Prevented the shortening of the colon caused by DSS colitis.
Essai clinique
Masse moléculaire

1818.00

Formule

C74H132N26O27
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu
Sequence Shortening

TEKKRRETVEREKE
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité
In Vitro: 

H2O : ≥ 50 mg/mL (27.50 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5501 mL 2.7503 mL 5.5006 mL
5 mM 0.1100 mL 0.5501 mL 1.1001 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation

Purity: 99.88%

SDS (396 KB)

COA (249 KB) RP-HPLC (267 KB) MS (72 KB) Elemental Analysis Report (107 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5501 mL 2.7503 mL 5.5006 mL 13.7514 mL
5 mM 0.1100 mL 0.5501 mL 1.1001 mL 2.7503 mL
10 mM 0.0550 mL 0.2750 mL 0.5501 mL 1.3751 mL
15 mM 0.0367 mL 0.1834 mL 0.3667 mL 0.9168 mL
20 mM 0.0275 mL 0.1375 mL 0.2750 mL 0.6876 mL
25 mM 0.0220 mL 0.1100 mL 0.2200 mL 0.5501 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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HEP-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HEP-1174641-44-2Human ezrin peptide (324-337)HEP1HEP 1HIVHCVHPVInfluenza VirusInterleukin RelatedHuman immunodeficiency virusHepatitis C virusHuman papillomavirusILinfectioncolitis modelInhibitorinhibitorinhibit

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