2. Apoptosis
  3. TNF Receptor
  4. Infliximab

インフリキシマブ  (Synonyms: Infliximab; Avakine; CT-P13)

製品番号: HY-P9970 純度: 90.30%
COA Technical Support

Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research.
The component ratio of this product is Active ingredient : Excipients = 9 : 47.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 170277-31-3

容量 価格（税別） 在庫状況 数量
1 mg $132 在庫あり
5 mg $330 在庫あり
10 mg $525 在庫あり
25 mg $825 在庫あり
50 mg $1300 在庫あり
100 mg $2100 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 27 publication(s) in Google Scholar

Infliximab Featured Recommendations:

インフリキシマブ 関連抗体

Top Publications Citing Use of Products

    Infliximab purchased from MedChemExpress. Usage Cited in: Adv Mater. 2024 Dec 6:e2412429.  [Abstract]

    Cascade repair probiotic gene editing system improves DSS-induced UC compared with clinical drugs. Daily change in body weight for each group, including Health, Control, 5-ASA (5-Aminosalicylic acid; 40 mg/kg; oral), vedolizumab (5 mg/kg; iv), ustekinumab (5 mg/kg; iv), infliximab (5 mg/kg; iv), and LGG-M@P, over 10 days. The above drugs were administered once every two days. Measurements of colonic tissue length in various groups on day 10. DAI changes throughout 10 days, calculated as the total of the stool consistency (0–3), fecal bleeding (0–4), and weight loss (0–4) indexes.

    Infliximab purchased from MedChemExpress. Usage Cited in: Adv Mater. 2024 Dec 6:e2412429.  [Abstract]

    Cascade repair probiotic gene editing system improves DSS-induced UC compared with clinical drugs. The groups are: Health, Control, 5-ASA (5-Aminosalicylic acid; 40 mg/kg; oral), vedolizumab (5 mg/kg; iv), ustekinumab (5 mg/kg; iv), infliximab (5 mg/kg; iv), and LGG-M@P, over 10 days. The above drugs were administered once every two days. Mice colonic sections stained with HE on day 10 following the indicated treatments.

    Infliximab purchased from MedChemExpress. Usage Cited in: Adv Mater. 2024 Dec 6:e2412429.  [Abstract]

    Cascade repair probiotic gene editing system improves DSS-induced UC compared with clinical drugs. The groups are: Health, Control, 5-ASA (5-Aminosalicylic acid; 40 mg/kg; oral), vedolizumab (5 mg/kg; iv), ustekinumab (5 mg/kg; iv), infliximab (5 mg/kg; iv), and LGG-M@P, over 10 days. The above drugs were administered once every two days. Colonic MPO levels on day 10.) Colonic TNF-α, IL-6, and IL-1β levels on day 10.

    Infliximab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 28:e16569.  [Abstract]

    38.5 mg/kg infliximab was i.v. administered twice, directly after SCI and 5 days after injury. Representative histoarchitectonics of the spinal cord injured site of SD rats treated with indicated therapeutics in comparison with non-treated SD rats evaluated by Hematoxylin and eosin, Heidenhain’s azan, and anti-GFAP staining were analyzed.

    Infliximab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 28:e16569.  [Abstract]

    38.5 mg/kg infliximab was i.v. administered twice, directly after SCI and 5 days after injury. Representative spinal cord MRI of the injured segment of treated rats was shown in comparison with non-treated SD rats. Hyperintense and hypointense areas were shown by red and blue, respectively.

    Infliximab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 28:e16569.  [Abstract]

    38.5 mg/kg infliximab was i.v. administered twice, directly after SCI and 5 days after injury. Mean MRI-based semi-quantitative severity score in groups of SD rats treated with the indicated therapeutics was compared with that in non-treated SD rats.

    Infliximab purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 May:118:109976.

    Infliximab (IFX; 10 mg/kg; i.p.; single) significantly increases the number of RGCs in mice.

    Infliximab purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 May:118:109976.

    Infliximab (IFX; 10 mg/kg; i.p.; single) decreases the p-p38/p38 level in NMDA-induced RGC injury mouse retinas.

    TNF Receptor アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research[1][2].
    The component ratio of this product is Active ingredient : Excipients = 9 : 47.

    Isotype

    Human IgG1 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    TNFSF2/TNFa
    体外実験

    TNF-α-treated adipocytes shows a significant 64% decrease in insulin-stimulated glucose uptake, whereas Infliximab (10 ng/mL) reverses TNF-α actions by significantly improving glucose incorporation in 3T3L1 adipocytes. Infliximab restores phosphorylation of substrate-2 and AKT by attenuating protein-tyrosine phosphatase 1B (PTP1B) activation. Infliximab ameliorates TNF-α-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring the insulin signalling pathway via PTP1B inhibition[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    インフリキシマブ 関連抗体
    体内実験

    A single injection of Infliximab (10 μg/g in 100 μL saline/dose ip) in diabetic TNF-α+/+) mice leads to suppression of the increased serum TNF-α and amelioration of the electrophysiological and biochemical deficits for at least 4 weeks. The increased TNF-α mRNA expression in diabetic dorsal root ganglion is also attenuated by Infliximab[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    Gene ID

    7124  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    分子量

    145.98 kDa

    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [Infliximab]
    輸送条件

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 kappa
    Biological Activity
    • Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 1µg/mL LPS for 24h with Infliximab (HY-P9970, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control，cells without incubation with primary antibody were used as the unlabeled control (black).
    • Loaded Infliximab on AHC2 biosensor, can bind TNF-alpha/TNFSF2 Protein, Human (HEK293, His-Avi, HY-P70527) with an affinity constant of <1.000E-11 M as determined in BLI assay.
    純度とドキュメンテーション

    純度: 90.30%

    COA (232 KB)

    Inhibitory Antibodies User Guide (603 KB)
    参考文献
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Infliximab Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Infliximab170277-31-3Avakine CT-P13 SB2 TA-650SB2SB 2SB-2TA650TA 650TA-650TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNFR2TNFR1anti-TNF-αmonoclonalautoimmuneanti-inflammatoryPTP1BdiabeticneuropathyInhibitorinhibitorinhibit

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    製品名:
    Infliximab
    製品番号:
    HY-P9970
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