2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ISM5939

ISM5939 is an orally active and selective ENPP1 inhibitor with an IC50 of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

ISM5939

ISM5939 構造式

CAS 番号 : 2965301-60-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 550 在庫あり
Solution
10 mM * 1 mL in DMSO USD 550 在庫あり
Solid
5 mg $500 在庫あり
10 mg $810 在庫あり
25 mg $1500 在庫あり
50 mg $2400 在庫あり
100 mg $3850 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

ISM5939 関連抗体

Top Publications Citing Use of Products

Phosphodiesterase (PDE) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

ISM5939 is an orally active and selective ENPP1 inhibitor with an IC50 of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity[1].

Parmacokinetics
Species Dose Route Bioavailability Clearance (CL) Vss
Mice[1] 1 mg/kg i.v. 32 % 14 mL/min/kg 0.53 L/kg
Mice[1] 5 mg/kg p.o. 32 % 14 mL/min/kg 0.53 L/kg
Mice[1] 1 mg/kg i.v. 49 % 14 mL/min/kg 1.1 L/kg
Mice[1] 5 mg/kg p.o. 49 % 14 mL/min/kg 1.1 L/kg
Mice[1] 0.5 mg/kg i.v. 45 % 2.0 mL/min/kg 0.63 L/kg
Mice[1] 1 mg/kg p.o. 45 % 2.0 mL/min/kg 0.63 L/kg
臨床実験
分子量

427.45

分子式

C20H18FN5O3S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C2=CC=CC=C2)C3=C(C=N1)N=C(C)N3CC4=C(F)C=C(S(N)(=O)=O)C=N4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 200 mg/mL (467.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3395 mL 11.6973 mL 23.3945 mL
5 mM 0.4679 mL 2.3395 mL 4.6789 mL
10 mM 0.2339 mL 1.1697 mL 2.3395 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3395 mL 11.6973 mL 23.3945 mL 58.4864 mL
5 mM 0.4679 mL 2.3395 mL 4.6789 mL 11.6973 mL
10 mM 0.2339 mL 1.1697 mL 2.3395 mL 5.8486 mL
15 mM 0.1560 mL 0.7798 mL 1.5596 mL 3.8991 mL
20 mM 0.1170 mL 0.5849 mL 1.1697 mL 2.9243 mL
25 mM 0.0936 mL 0.4679 mL 0.9358 mL 2.3395 mL
30 mM 0.0780 mL 0.3899 mL 0.7798 mL 1.9495 mL
40 mM 0.0585 mL 0.2924 mL 0.5849 mL 1.4622 mL
50 mM 0.0468 mL 0.2339 mL 0.4679 mL 1.1697 mL
60 mM 0.0390 mL 0.1950 mL 0.3899 mL 0.9748 mL
80 mM 0.0292 mL 0.1462 mL 0.2924 mL 0.7311 mL
100 mM 0.0234 mL 0.1170 mL 0.2339 mL 0.5849 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ISM5939 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ISM59392965301-60-2ISM 5939ISM-5939Phosphodiesterase (PDE)ENPP1InhibitorAntitumorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
ISM5939
製品番号:
HY-176708
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.