2. PI3K/Akt/mTOR Metabolic Enzyme/Protease
  3. mTOR Endogenous Metabolite
  4. L-Leucine-d3

L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.

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L-Leucine-d<sub>3</sub>

L-Leucine-d3 Chemische Struktur

CAS. Nr. : 87828-86-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Solution
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Based on 3 publication(s) in Google Scholar

Other Forms of L-Leucine-d3:

L-Leucine-d3 Related Antibodies

Top Publications Citing Use of Products

Alle mTOR Isoform-spezifische Produkte anzeigen:

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mTOR mTORC1 mTORC2

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
Human Endogenous Metabolite Microbial Metabolite

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Beschreibung

L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Leucine-d3 Related Antibodies
Molekulargewicht

134.19

Formel

C6H10D3NO2
CAS. Nr.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C(C)C[C@H](N)C(O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

H2O : ≥ 10 mg/mL (74.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.4521 mL 37.2606 mL 74.5212 mL
5 mM 1.4904 mL 7.4521 mL 14.9042 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 99.98%

SDS (394 KB)

COA (246 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.4521 mL 37.2606 mL 74.5212 mL 186.3030 mL
5 mM 1.4904 mL 7.4521 mL 14.9042 mL 37.2606 mL
10 mM 0.7452 mL 3.7261 mL 7.4521 mL 18.6303 mL
15 mM 0.4968 mL 2.4840 mL 4.9681 mL 12.4202 mL
20 mM 0.3726 mL 1.8630 mL 3.7261 mL 9.3151 mL
25 mM 0.2981 mL 1.4904 mL 2.9808 mL 7.4521 mL
30 mM 0.2484 mL 1.2420 mL 2.4840 mL 6.2101 mL
40 mM 0.1863 mL 0.9315 mL 1.8630 mL 4.6576 mL
50 mM 0.1490 mL 0.7452 mL 1.4904 mL 3.7261 mL
60 mM 0.1242 mL 0.6210 mL 1.2420 mL 3.1050 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Leucine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Leucine-d387828-86-2mTOREndogenous MetaboliteMammalian target of RapamycinInhibitorinhibitorinhibit

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