2. PI3K/Akt/mTOR Stem Cell/Wnt Autophagy
  3. GSK-3 Wnt β-catenin Autophagy
  4. Laduviglusib

Laduviglusib  (Synonyms: CHIR-99021; CT99021)

製品番号: HY-10182G
取扱説明書 Technical Support

Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

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Laduviglusib

Laduviglusib 構造式

CAS 番号 : 252917-06-9

容量 価格（税別） 在庫状況 数量
10 mg $1060 在庫あり
50 mg $3150 在庫あり
100 mg $5000 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Laduviglusib 関連抗体

Top Publications Citing Use of Products

GSK-3 アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
GSK-3 GSK-3α GSK-3β

Wnt アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

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製品説明

Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

IC50 & Target[1]

GSK-3β

6.7 nM (IC50)

GSK-3α

10 nM (IC50)

CDC2

8800 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
CHO EC50
0.13 μM
Compound: 1
Inhibition of GSK3 in CHO cells expressing insulin receptor assessed as activation of glycogen synthase measured after 30 mins in presence of glucose-6-phosphate by filter paper assay
Inhibition of GSK3 in CHO cells expressing insulin receptor assessed as activation of glycogen synthase measured after 30 mins in presence of glucose-6-phosphate by filter paper assay
[PMID: 31926786]
HepG2 EC50
1.5 μM
Compound: 1, CHIR-99021
Inhibition of GSK3-beta in human HepG2 cells assessed as incorporation of [3H]glucose into glycogen after 3 hrs by liquid scintillation counting
Inhibition of GSK3-beta in human HepG2 cells assessed as incorporation of [3H]glucose into glycogen after 3 hrs by liquid scintillation counting
[PMID: 22261023]
体外実験

Laduviglusib (GMP) (20 μM, 21 days) transdifferentiates mouse fibroblasts to neurons (determined by increased number of TAUEGFP-/TUJ1-positive neuronal cells)[1].
Laduviglusib (GMP) (3-5 μM, 2 days) induces somatic cells differentiation of pluripotent stem (PS) cells (the detailed method refers to the reference)[2].
Laduviglusib (GMP) (12 μM, 5 days) converts human fibroblasts (HFF) into functional cardiomyocytes[3].
Laduviglusib (GMP) (3 μM, 4 days, hESCs) activates the canonical WNT signaling pathway, confirmed by β-catenin translocation into the nucleus[4].
Laduviglusib (GMP) (in MEFs expressing MyoD) enhances the marked increase in the number of proliferative cells led by RepSox (GMP) (HY-13012G) together with Forskolin (HY-15371)[5].
Laduviglusib (GMP) (5 μM, 1 day) can be used to generate islets (hCiPSC-islets) from human chemically induced pluripotent stem cells (hCiPSC)[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Laduviglusib 関連抗体
分子量

465.34

分子式

C22H18Cl2N8
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C
輸送条件

Shipping with dry ice.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
体外: 

DMSO : 4.55 mg/mL (9.78 mM; warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1490 mL 10.7448 mL 21.4897 mL
5 mM 0.4298 mL 2.1490 mL 4.2979 mL
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1490 mL 10.7448 mL 21.4897 mL 53.7242 mL
5 mM 0.4298 mL 2.1490 mL 4.2979 mL 10.7448 mL
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Laduviglusib Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Laduviglusib (GMP)252917-06-9CHIR-99021 (GMP)CT99021 (GMP)GSK-3Wntβ-cateninAutophagyGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninGMPWnt/β-cateninES cellES-D3 celladipogenesisGI injuryreprogramPSCInhibitorinhibitorinhibit

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製品名:
Laduviglusib
製品番号:
HY-10182G
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