Lysophosphatidylcholines

Name: Lysophosphatidylcholines
Brand: MedChemExpress
SKU: HY-139414
Rating: 5.0 (6 reviews)

Cat. No.: HY-139414 Pureté: 99.9%: Fiche technique
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Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.

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CAS No. : 9008-30-4

Size	Stock	Quantité
Échantillon gratuit (0.1 - 0.2 mg)	Appliquer maintenant
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
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Based on 6 publication(s) in Google Scholar

6 Publications Citing Use of MCE Lysophosphatidylcholines

IHC

In Vivo Efficacy Study

Cell Proliferation/Viability Assay

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 14:e17330. [Abstract]; Addition of GPLs (PCs, PEs, LysoPCs, and LysoPAs; each at 10 µg/mL) to EAC cells for 5 days attenuated the inhibitory effect of TRIM15 knockdown or FOXRED1 overexpression on cell proliferation.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; LPC (1 µL of 1% solution, single round-window administration) induced decreased MBP expression and an increase in F4/80-positive cells, indicating demyelination of spiral ganglion neurons (SGNs).

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; In the cochleae of mice treated with LPC (1 µL of 1% solution, single round-window administration), MBP was co-localized with F4/80-labeled RCMs in both APOE3 and APOE4 mice; however, APOE4 mice exhibited a lower proportion of MBP-positive RCMs with reduced MBP fluorescence intensity.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; Western blot analysis of N-GSDMD, cleaved caspase-11, pro-caspase-11, and β-actin in peripheral blood monocytes (left) and peritoneal macrophages (right) from LPS and CLP model mice following treatment with 150 μg A box, 10 mg/kg LPC, or 50 mg/kg DSF. All experiments were performed at least three times. CLP, cecum ligation and puncture; DSF, disulfiram; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2024 Aug 16;230(2):298-308. [Abstract]; Survival curves of LPS (left) and CLP (right) model mice after treatment with 50 mg/kg VX-765 or 10 mg/kg LPC (n = 10). CLP + LPC vs. CLP, **P < 0.01; LPS + LPC vs. LPS, **P < 0.01. All data were collected from at least three independent experiments. CLP, cecum ligation and puncture; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.

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Activité biologique
Pureté et documentation
Références
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Description

IC₅₀ & Target

IL-1β

ERK1

ERK2

In Vitro

Lysophosphatidylcholine (3-100 μM, 24 h) reduced HUVEC viability^[1].
Lysophosphatidylcholines (12.5μM, 4 h) upregulates gene expression of IL-1β in human peripheral blood monocytes^[2].
Lysophosphatidylcholines (75μM, 24 h) induces apoptosis in HUVEC through a p38-mitogen-activated protein kinase-dependent mechanism^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HUVEC
Concentration:	3 μM, 10μM, 30 μM, 100 μM
Incubation Time:	24 h
Result:	Reduced HUVEC viability in a concentration-dependent manner.

Western Blot Analysis^[3]

Cell Line:	HUVEC
Concentration:	75 μM
Incubation Time:	24 h
Result:	Showed both ERK1/2 and p38-MAPK phosphorylation.

In Vivo

Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) protects against sepsis-induced lethality on albino ICR mice^[4].
Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) enhances bacterial clearance, blocks cecal ligation and puncture (CLP)-induced neutrophil deactivation and increases bactericidal activity of neutrophils^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Albino ICR mice ^[4]
Dosage:	0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	Oral
Result:	Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg.

CAS No.

9008-30-4

Appearance

Solid

Color

White to off-white

SMILES

[Lysophosphatidylcholines]

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

H₂O : 100 mg/mL (Need ultrasonic)

Methanol : 25 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Calculateur de molarité
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99.9%

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Fiche technique (272 KB) SDS (393 KB)

COA (241 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Kim E A, et al. Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress [J]. The Journal of Maternal-Fetal & Neonatal Medicine, 2009, 22(4): 325-331. [Content Brief]

[2]. Liu-Wu Y, et al. Lysophosphatidylcholine induces the production of IL-1β by human monocytes [J]. Atherosclerosis, 1998, 137(2): 351-357. [Content Brief]

[3]. Takahashi M, et al. Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism [J]. Atherosclerosis, 2002, 161(2): 387-394. [Content Brief]

[4]. Yan J J, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis [J]. Nature medicine, 2004, 10(2): 161-167. [Content Brief]