Lysophosphatidylcholines

Name: Lysophosphatidylcholines
Brand: MedChemExpress
SKU: HY-139414
Rating: 5.0 (6 reviews)

製品番号: HY-139414 純度: 99.9%: Data Sheet SDS COA 取扱説明書
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Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 9008-30-4

容量	価格（税別）	在庫状況	数量
>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
5 mg	$80	在庫あり	Estimated Time of Arrival: December 31
10 mg	$130	在庫あり	Estimated Time of Arrival: December 31
25 mg	$220	在庫あり	Estimated Time of Arrival: December 31
50 mg	$310	在庫あり	Estimated Time of Arrival: December 31
100 mg	$430	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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カスタマーレビュー

Based on 6 publication(s) in Google Scholar

顧客検証

IHC

In Vivo Efficacy Study

Cell Proliferation/Viability Assay

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 14:e17330. [Abstract]; Addition of GPLs (PCs, PEs, LysoPCs, and LysoPAs; each at 10 µg/mL) to EAC cells for 5 days attenuated the inhibitory effect of TRIM15 knockdown or FOXRED1 overexpression on cell proliferation.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; LPC (1 µL of 1% solution, single round-window administration) induced decreased MBP expression and an increase in F4/80-positive cells, indicating demyelination of spiral ganglion neurons (SGNs).

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; In the cochleae of mice treated with LPC (1 µL of 1% solution, single round-window administration), MBP was co-localized with F4/80-labeled RCMs in both APOE3 and APOE4 mice; however, APOE4 mice exhibited a lower proportion of MBP-positive RCMs with reduced MBP fluorescence intensity.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Apr 21;11(1):190. [Abstract]; Western blot analysis of N-GSDMD, cleaved caspase-11, pro-caspase-11, and β-actin in peripheral blood monocytes (left) and peritoneal macrophages (right) from LPS and CLP model mice following treatment with 150 μg A box, 10 mg/kg LPC, or 50 mg/kg DSF. All experiments were performed at least three times. CLP, cecum ligation and puncture; DSF, disulfiram; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.

: Lysophosphatidylcholines purchased from MedChemExpress. Usage Cited in: J Infect Dis. 2024 Aug 16;230(2):298-308. [Abstract]; Survival curves of LPS (left) and CLP (right) model mice after treatment with 50 mg/kg VX-765 or 10 mg/kg LPC (n = 10). CLP + LPC vs. CLP, **P < 0.01; LPS + LPC vs. LPS, **P < 0.01. All data were collected from at least three independent experiments. CLP, cecum ligation and puncture; LPC, lysophosphatidylcholine; LPS, lipopolysaccharide.

Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

p38 MAPK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

ERK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

ERK ERK1 ERK2 ERK5 ERK8

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

IL-1β

ERK1

ERK2

体外実験

Lysophosphatidylcholine (3-100 μM, 24 h) reduced HUVEC viability^[1].
Lysophosphatidylcholines (12.5μM, 4 h) upregulates gene expression of IL-1β in human peripheral blood monocytes^[2].
Lysophosphatidylcholines (75μM, 24 h) induces apoptosis in HUVEC through a p38-mitogen-activated protein kinase-dependent mechanism^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	HUVEC
Concentration:	3 μM, 10μM, 30 μM, 100 μM
Incubation Time:	24 h
Result:	Reduced HUVEC viability in a concentration-dependent manner.

Western Blot Analysis^[3]

Cell Line:	HUVEC
Concentration:	75 μM
Incubation Time:	24 h
Result:	Showed both ERK1/2 and p38-MAPK phosphorylation.

体内実験

Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) protects against sepsis-induced lethality on albino ICR mice^[4].
Lysophosphatidylcholines (0.1-20 mg/kg, Oral, single dose) enhances bacterial clearance, blocks cecal ligation and puncture (CLP)-induced neutrophil deactivation and increases bactericidal activity of neutrophils^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Albino ICR mice ^[4]
Dosage:	0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	Oral
Result:	Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg.

CAS 番号

9008-30-4

Appearance

Solid

Color

White to off-white

SMILES

[Lysophosphatidylcholines]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 100 mg/mL (Need ultrasonic)

Methanol : 25 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

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純度とドキュメンテーション

純度: 99.9%

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データシート (272 KB) SDS (393 KB)

COA (241 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Kim E A, et al. Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress [J]. The Journal of Maternal-Fetal & Neonatal Medicine, 2009, 22(4): 325-331. [Content Brief]

[2]. Liu-Wu Y, et al. Lysophosphatidylcholine induces the production of IL-1β by human monocytes [J]. Atherosclerosis, 1998, 137(2): 351-357. [Content Brief]

[3]. Takahashi M, et al. Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism [J]. Atherosclerosis, 2002, 161(2): 387-394. [Content Brief]

[4]. Yan J J, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis [J]. Nature medicine, 2004, 10(2): 161-167. [Content Brief]