MSAB

Name: MSAB
Brand: MedChemExpress
SKU: HY-120697
Rating: 5.0 (50 reviews)

Cat. No.: HY-120697 Purity: 99.77%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 173436-66-3

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 50 publication(s) in Google Scholar

50 Publications Citing Use of MCE MSAB

Cell Proliferation/Viability Assay

Histological Imaging/Staining

Cell Migration/Invasion Assay

: MSAB purchased from MedChemExpress. Usage Cited in: Exploration. 2025 Jun 08.; Quantitative assessment of the impact of MSAB (10 μM; 48 h) on the RL-QN15-induced hESCs proliferation and viability.

: MSAB purchased from MedChemExpress. Usage Cited in: Exploration. 2025 Jun 08.; Representative images demonstrate the effectiveness of RL-QN15 in repairing hESC scratches with and without MSAB (10 μM; 0–48 h).

: MSAB purchased from MedChemExpress. Usage Cited in: Exploration. 2025 Jun 08.; Effect of MSAB (10 μM; 72 h) on the expression of the proliferation-related stemness-related protein CK19 in hESCs treated with 10 nM RL-QN15. GAPDH was used as an internal control.

: MSAB purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Apr 27:S2090-1232(25)00282-6. [Abstract]; HE staining images of skin wound tissue with MSAB (20 mg/kg, ip, every two days for two weeks).

: MSAB purchased from MedChemExpress. Usage Cited in: Cancers (Basel). 2023 Mar 16;15(6):1801.; MSAB (5 μM) attenuates the activity of Wnt3a and β-caten in SiHa cells.

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View All Wnt Isoform Specific Products:

View All Isoforms

Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Wnt/β-catenin^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.58 μM Compound: 132; MSAB	Anticancer activity against human HCT-116 cells assessed as reduction in cell viability Anticancer activity against human HCT-116 cells assessed as reduction in cell viability	[PMID: 33445154]

In Vitro

MSAB (2-10 μM) selectively decreases cell viability of Wnt-dependent cells while showing little effect on Wnt-independent cells and normal human cells^[1].
MSAB (0.01-10 μM; 20 h) inhibits T-cell factor (TCF) luciferase reporter activity in HCT116 cells^[1].
MSAB (20 h) suppresses the Wnt3a-induced TOP-Luc activation and increases of active β-catenin levels in HEK293T cells^[1].
MSAB (0.5-10 μM; 20 h) decreases mRNA and protein levels of endogenous Wnt target genes in HCT116 cells^[1].
MSAB (5 μM; 16 h) induces degradation of β-catenin in a proteasome-dependent manner in HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in mouse xenograft model^[1].
MSAB (10-20 mg/kg; i.p. twice daily for 2 weeks) inhibits tumor growth of MMTV-Wnt1 transgenic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic nude mice (5-6 weeks) are injected HCT116, HT115, H23, or H460 cells^[1]
Dosage:	10, 20 mg/kg
Administration:	I.p. daily for 2 weeks
Result:	Reduced the size and weight of various types of Wnt-dependent HCT116, HT115, and H23 tumors.

분자량

305.35

화학식

C₁₅H₁₅NO₄S

CAS No.

173436-66-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC(NS(=O)(C2=CC=C(C=C2)C)=O)=C1)OC

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : 250 mg/mL (818.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2749 mL	16.3747 mL	32.7493 mL
5 mM	0.6550 mL	3.2749 mL	6.5499 mL
10 mM	0.3275 mL	1.6375 mL	3.2749 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.77%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (247 KB) HNMR (256 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Hwang SY, et, al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Rep. 2016 Jun 28;16(1):28-36. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2749 mL	16.3747 mL	32.7493 mL	81.8733 mL
	5 mM	0.6550 mL	3.2749 mL	6.5499 mL	16.3747 mL
	10 mM	0.3275 mL	1.6375 mL	3.2749 mL	8.1873 mL
	15 mM	0.2183 mL	1.0916 mL	2.1833 mL	5.4582 mL
	20 mM	0.1637 mL	0.8187 mL	1.6375 mL	4.0937 mL
	25 mM	0.1310 mL	0.6550 mL	1.3100 mL	3.2749 mL
	30 mM	0.1092 mL	0.5458 mL	1.0916 mL	2.7291 mL
	40 mM	0.0819 mL	0.4094 mL	0.8187 mL	2.0468 mL
	50 mM	0.0655 mL	0.3275 mL	0.6550 mL	1.6375 mL
	60 mM	0.0546 mL	0.2729 mL	0.5458 mL	1.3646 mL
	80 mM	0.0409 mL	0.2047 mL	0.4094 mL	1.0234 mL
	100 mM	0.0327 mL	0.1637 mL	0.3275 mL	0.8187 mL

MSAB Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MSAB173436-66-3Wntβ-cateninBeta catenindegradationanti-tumorcancerInhibitorinhibitorinhibit

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MSAB

고객리뷰

MSAB Related Antibodies

50 Publications Citing Use of MCE MSAB

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Wnt Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

MSAB Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

MSAB Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report