2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. N-(α-Linolenoyl) tyrosine

N-(α-Linolenoyl) tyrosine  (Synonyms: NLT)

Cat. No.: HY-145512 Purity: 98.98%
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N-(α-Linolenoyl) tyrosine (NLT) is a dopaminergic agonist capable of crossing the blood-brain barrier. N-(α-Linolenoyl) tyrosine increases the level, turnover rate and release amount of dopamine in the striatum. N-(α-Linolenoyl) tyrosine modulates rotational behavior in a rat model with unilateral striatal injury and alleviates excessive blinking symptoms in models induced by dopamine-depleting agents. N-(α-Linolenoyl) tyrosine can be used for research on Parkinson's disease and idiopathic blepharospasm.

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N-(α-Linolenoyl) tyrosine

N-(α-Linolenoyl) tyrosine 화학구조

CAS No. : 259143-19-6

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg   견적 받기  
50 mg   견적 받기  

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N-(α-Linolenoyl) tyrosine Related Antibodies

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제품 설명

N-(α-Linolenoyl) tyrosine (NLT) is a dopaminergic agonist capable of crossing the blood-brain barrier. N-(α-Linolenoyl) tyrosine increases the level, turnover rate and release amount of dopamine in the striatum. N-(α-Linolenoyl) tyrosine modulates rotational behavior in a rat model with unilateral striatal injury and alleviates excessive blinking symptoms in models induced by dopamine-depleting agents. N-(α-Linolenoyl) tyrosine can be used for research on Parkinson's disease and idiopathic blepharospasm[1].

In Vivo

N-(α-Linolenoyl) tyrosine (100 mg/kg; i.p.; single injection) reverses rotational behavior in 6-OH-DA-lesioned rats, increasing ipsilateral turns to 98% and elevating striatal DA levels by 32% while reducing DA metabolite levels and turnover ratios, matching the efficacy of D-amphetamine[1].
N-(α-Linolenoyl) tyrosine (25 mg/kg; i.p.; daily; 14 days) completely reverses the exaggerated eye-blinking induced by the dopamine-depleting agent Ro4-1284 in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rat (male, 150-200 g, unilateral left striatal 6-hydroxydopamine lesion-induced Parkinson's disease)[1]
Dosage: 100 mg/kg
Administration: i.p.; single injection
Result: Reversed rotational behavior of 6-OH-DA-lesioned rats, inducing 98 left (ipsilateral to lesion) turns and 2 right (contralateral to lesion) turns over 30 minutes, representing 98% ipsilateral turns.
Animal Model: Sprague-Dawley rat (male, Ro4-1284-induced benign essential blepharospasm)[1]
Dosage: 25 mg/kg
Administration: i.p.; daily; 14 days
Result: Reduced Ro4-1284-induced eye-blinking rate from 19.08 to 5.00 blinks per minute, a level comparable to the normal rat eye-blinking rate of 5.16 blinks per minute.
분자량

441.60

화학식

C27H39NO4
CAS No.
Appearance

Solid

Color

Off-white to light brown

Sequence

{α-Linolenoyl}-Tyr
Sequence Shortening

{α-Linolenoyl}-Y
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

순도&문서
References
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N-(α-Linolenoyl) tyrosine Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-(α-Linolenoyl) tyrosine259143-19-6NLTDopamine ReceptorL-tyrosineParkinson’s diseaseα-linolenic acidunilateral striatal lesion rat modelsblood-brain barrier6-OH-DA-lesioned ratsstriatal dopaminedopaminergic agonistRo4-1284essential blepharospasmInhibitorinhibitorinhibit

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상품명:
N-(α-Linolenoyl) tyrosine
Cat. No.:
HY-145512
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