N1-Acetylspermidine hydrochloride

Name: N1-Acetylspermidine hydrochloride
Brand: MedChemExpress
SKU: HY-113056A
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-113056A Reinheit: 99.13%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

N1-Acetylspermidine hydrochloride Chemische Struktur

CAS. Nr. : 34450-16-3

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

or Massenanfrage

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 Customer Validation

Other Forms of N1-Acetylspermidine hydrochloride:

N1-Acetylspermidine-d₃ hydrochloride In-stock
N1-Acetylspermidine-d₆ hydrochloride Angebot einholen
N1-Acetylspermidine hydrochloride (Standard) Angebot einholen

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Human Endogenous Metabolite Microbial Metabolite

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

In Vitro

N1-Acetylspermidine (1 mM) hydrochloride is less efficient than Spermidine (HY-B1776) and N⁸-acetylspermidine (HY-113253A) in inducing DNA cleavage at apurinic sites^[3].
N1-Acetylspermidine (500 μM) hydrochloride combined with Procyanidins can increase the proportion of apoptotic SW620 cells (colon cancer cell line)^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

260.20

Formel

C₉H₂₃Cl₂N₃O

CAS. Nr.

34450-16-3

Appearance

Solid

Color

White to light yellow

SMILES

CC(NCCCNCCCCN)=O.[H]Cl.[H]Cl

Structure Classification

Others

Initial Source

Endogenous metabolite

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 25 mg/mL (96.08 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8432 mL	19.2160 mL	38.4320 mL
5 mM	0.7686 mL	3.8432 mL	7.6864 mL
10 mM	0.3843 mL	1.9216 mL	3.8432 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.13%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (242 KB) HNMR (281 KB) RP-HPLC (203 KB) MS (183 KB) Elemental Analysis Report (101 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84. [Content Brief]

[2]. Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7. [Content Brief]

[3]. Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. [Content Brief]

[4]. Kato M, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus. 2023 Oct 10;2(10):pgad306. [Content Brief]

[5]. Gossé F, et al. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol. 2006 Aug;29(2):423-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8432 mL	19.2160 mL	38.4320 mL	96.0799 mL
	5 mM	0.7686 mL	3.8432 mL	7.6864 mL	19.2160 mL
	10 mM	0.3843 mL	1.9216 mL	3.8432 mL	9.6080 mL
	15 mM	0.2562 mL	1.2811 mL	2.5621 mL	6.4053 mL
	20 mM	0.1922 mL	0.9608 mL	1.9216 mL	4.8040 mL
	25 mM	0.1537 mL	0.7686 mL	1.5373 mL	3.8432 mL
	30 mM	0.1281 mL	0.6405 mL	1.2811 mL	3.2027 mL
	40 mM	0.0961 mL	0.4804 mL	0.9608 mL	2.4020 mL
	50 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.9216 mL
	60 mM	0.0641 mL	0.3203 mL	0.6405 mL	1.6013 mL
	80 mM	0.0480 mL	0.2402 mL	0.4804 mL	1.2010 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.