2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. NBQX disodium

NBQX disodium  (Synonyms: FG9202 disodium)

製品番号: HY-15068A 純度: 98.96%
COA 取扱説明書 Technical Support

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.

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CAS 番号 : 479347-86-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 108 在庫あり
Solution
10 mM * 1 mL in DMSO USD 108 在庫あり
Solid
5 mg $99 在庫あり
10 mg $150 在庫あり
25 mg $300 在庫あり
50 mg $450 在庫あり
100 mg $675 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 20 publication(s) in Google Scholar

Other Forms of NBQX disodium:

NBQX disodium 関連抗体

Top Publications Citing Use of Products

    NBQX disodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr:139:156457.

    Representative images of FJB-positive neurons, marking degenerating neurons in the CA1, CA3, and DG regions post-TBI. The results showed that, compared with the TBI‑vehicle group, the NBQX (30 mg/kg) treatment group exhibited a significant reduction in neuronal death in the CA1, CA3, and DG regions of the rat hippocampus.

    NBQX disodium purchased from MedChemExpress. Usage Cited in: Nature. 2024 Jul;631(8022):826-834.  [Abstract]

    Representative images showing the calcein-PI staining of cultured neurons from Asic1a+/+ and Asic1a-/- mice with different treatments. GluR-B: glutamate receptor blockers consisted of 50 μM D-AP5, 10 μM NBQX and 10 μM LY341495.

    NBQX disodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080.  [Abstract]

    NBQX (1 mg/kg/d; i.p.; once daily for 4 weeks). UNEL showed that activation of AMPAR increased cardiomyocyte apoptosis in vitro, but incubation with a NF-κB-specific inhibitor BAY 11-7082 reversed this effect.

    NBQX disodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080.  [Abstract]

    NBQX (NB, 1 mg/kg/d; i.p.; once daily for 4 weeks). Apoptosis measurement by flow cytometry shows that activation of AMPAR increased apoptosis, but this effect was reversed by BAY 11-7082.

    NBQX disodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080.  [Abstract]

    NBQX (NB, 30 μM; added to the medium 6 h before hypoxia stimulation). ELISA method was employed to evaluate TNF-α, IL-1β, IL-6 and IL-10 levels in the culture medium of each group(n = 6). Inhibition of AMPA receptor decreased pro-inflammatory factor production and increased anti-inflammatory factor production. *:p < 0.05;**:p < 0.01;***:p < 0.005; ****:p < 0.001.

    NBQX disodium purchased from MedChemExpress. Usage Cited in: Theranostics. 2023 May 11;13(9):2946-2961.  [Abstract]

    NBQX (10 nmol/mL, 1 µl /side, via microinjection into the mPFC) and D-AP5 effectively reduce the express of CaMKIIα, pCREB/CREB, BDNF, and TrkB in mPFC, while activation of HPC-mPFC prevents the decrease (* LPS+CNO versus LPS, # LPS+NBQX/D-AP5+CNO versus LPS+CNO). Data were presented as mean ± SEM. n=5/group. * p < 0.05, ** p < 0.01, # p<0.05, ## p<0.01.

    iGluR アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    AMPA Receptor NMDA Receptor Kainate Receptor

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].

    IC50 & Target

    AMPA receptor[1]
    体外実験

    NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    NBQX disodium 関連抗体
    体内実験

    NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2].
    NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2]
    Dosage: 20 mg/kg
    Administration: IP; for 3 days
    Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
    分子量

    380.24

    分子式

    C12H6N4Na2O6S
    CAS 番号
    Appearance

    Solid

    Color

    Brown to dark brown

    SMILES

    O=C([N-]1)C([N-]C2=C1C3=C(C([N+]([O-])=O)=C2)C(S(N)(=O)=O)=CC=C3)=O.[Na+].[Na+]
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (262.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 50 mg/mL (131.50 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6299 mL 13.1496 mL 26.2992 mL
    5 mM 0.5260 mL 2.6299 mL 5.2598 mL
    10 mM 0.2630 mL 1.3150 mL 2.6299 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

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    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1 mg/mL (2.63 mM); Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 1 mg/mL (2.63 mM); Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 98.96%

    COA (257 KB) HNMR (268 KB) RP-HPLC (250 KB) MS (229 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.6299 mL 13.1496 mL 26.2992 mL 65.7480 mL
    5 mM 0.5260 mL 2.6299 mL 5.2598 mL 13.1496 mL
    10 mM 0.2630 mL 1.3150 mL 2.6299 mL 6.5748 mL
    15 mM 0.1753 mL 0.8766 mL 1.7533 mL 4.3832 mL
    20 mM 0.1315 mL 0.6575 mL 1.3150 mL 3.2874 mL
    25 mM 0.1052 mL 0.5260 mL 1.0520 mL 2.6299 mL
    30 mM 0.0877 mL 0.4383 mL 0.8766 mL 2.1916 mL
    40 mM 0.0657 mL 0.3287 mL 0.6575 mL 1.6437 mL
    50 mM 0.0526 mL 0.2630 mL 0.5260 mL 1.3150 mL
    60 mM 0.0438 mL 0.2192 mL 0.4383 mL 1.0958 mL
    80 mM 0.0329 mL 0.1644 mL 0.3287 mL 0.8218 mL
    100 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6575 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    NBQX disodium Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NBQX disodium479347-86-9FG9202 disodiumiGluRIonotropic glutamate receptorsAMPneuroprotectiveischaemiaNMDAInhibitorinhibitorinhibit

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