1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Otenzepad

Otenzepad (Synonyms: AF-DX 116)

Cat. No.: HY-101381 Purity: >98.0%
Handling Instructions

Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC50 values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively.

For research use only. We do not sell to patients.

Otenzepad Chemical Structure

Otenzepad Chemical Structure

CAS No. : 102394-31-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 366 In-stock
Estimated Time of Arrival: December 31
1 mg USD 135 In-stock
Estimated Time of Arrival: December 31
5 mg USD 395 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Otenzepad (AF-DX 116) is a selective and competitive M2 muscarinic acetylcholine receptor antagonist, with IC50 values of 640 nM and 386 nM for rabbit peripheral lung and rat heart, respectively[1].

IC50 & Target

640 nM (M2 muscarinic acetylcholine receptor in rabbit peripheral lung), 386 nM (M2 muscarinic acetylcholine receptor in rat heart)[1].

In Vivo

Otenzepad (0.5, 1 mg/kg, s.c., in rats) significantly improved win-stay acquisition relative to vehicle-injected controls[2].
Otenzepad (2 mg/kg, s.c., in rats) significantly improved retention relative to vehicle controls[2].
Otenzepad (0.3, 1.0, or 3.0 mg/kg, ip, in mice) potentiates the effects of glucose and reverses the effects of insulin on memory[3].

Animal Model: Forty-eight male Long-Evans rats (325-350 g)[2].
Dosage: 0.25, 0.5, 1.0 and 2.0 mg/kg.
Administration: S.C. on the dorsum of the neck once.
Result: Doses of 0.5 and 1.0 mg/kg significantly improved acquisition relative to vehicle controls, while doses of 0.25 and 2.0 mg/kg had no effect.
Animal Model: Adult male Swiss mice (age 60–70 days; weight 25-30 g)[3].
Dosage: 0.3, 1.0, or 3.0 mg/kg.
Administration: IP once.
Result: Enhanced retention in an inverted-U dose–response manner, with significant enhancement seen at 1.0 mg/kg (U15,15 = 49, p < 0.02, compared with saline-saline-injected control group).
Molecular Weight

421.54

Formula

C₂₄H₃₁N₅O₂

CAS No.

102394-31-0

SMILES

O=C1NC2=CC=CN=C2N(C(CN3C(CN(CC)CC)CCCC3)=O)C4=CC=CC=C14

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

OtenzepadAF-DX 116mAChRMuscarinic acetylcholine receptormemory,Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Otenzepad
Cat. No.:
HY-101381
Quantity:
MCE Japan Authorized Agent: