2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (S)-4C3HPG

(S)-4C3HPG  (Synonyms: (S)-4-Carboxy-3-hydroxyphenylglycine)

Cat. No.: HY-100840
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(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice.

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(S)-4C3HPG

(S)-4C3HPG 화학구조

CAS No. : 85148-82-9

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Other Forms of (S)-4C3HPG:

(S)-4C3HPG Related Antibodies

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제품 설명

(S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
> 100 μM
Compound: 21
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
[PMID: 15801843]
HEK293 IC50
40 μM
Compound: 34
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells
Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells
[PMID: 10229625]
분자량

211.17

화학식

C9H9NO5
CAS No.
SMILES

OC1=C(C(O)=O)C=CC([C@H](N)C(O)=O)=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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(S)-4C3HPG Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-4C3HPG85148-82-9(S)-4-Carboxy-3-hydroxyphenylglycinemGluRMetabotropic glutamate receptorsmetabotropic glutamate receptormGluR 1aGluR2anticonvulsantaudiogenic seizuresDBA/2Inhibitorinhibitorinhibit

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(S)-4C3HPG
Cat. No.:
HY-100840
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