(RS)-4C3HPG
(RS)-4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system, and it is also an agonist at mGluR2/3. (RS)-4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model.
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- CAS No.: 134052-66-7
- Formule: C9H9NO5
- Masse moléculaire:211.17
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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mGluR 1 |
mGluR2 |
mGluR3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
200 μM
Compound: 3a
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Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
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10.1016/0960-894X(96)00104-7 |
Chemical Information
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CAS No. 134052-66-7
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Masse moléculaire 211.17
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Formule C9H9NO5
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SMILES
O=C(O)C(N)C1=CC=C(C(O)=O)C(O)=C1
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Synonyms
4-Carboxy-3-hydroxyphenylglycine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Gerber U, et al. 4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine), a weak agonist at metabotropic glutamate receptors, occludes the action of trans-ACPD in hippocampus. Eur J Pharmacol. 1992 Oct 20;221(2-3):401-2. [Content Brief]
[2]. Henrich-Noack P, et al. The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils. Neuroreport. 1998 Apr 20;9(6):985-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(RS)-4C3HPG Related Classifications
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