SCH-202676 hydrobromide

製品番号: HY-110012 純度: 98.85%: Data Sheet SDS COA 取扱説明書
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SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 hydrobromide has antiviral activity and inhibits 3CL^pro in a time-dependent manner with an IC₅₀ value of 0.655 μM.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

SCH-202676 hydrobromide 構造式

CAS 番号 : 265980-25-4

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 82	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 82	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$75	在庫あり	Estimated Time of Arrival: December 31
10 mg	$128	在庫あり	Estimated Time of Arrival: December 31
25 mg	$280	在庫あり	Estimated Time of Arrival: December 31
50 mg	$475	在庫あり	Estimated Time of Arrival: December 31
100 mg	$800	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of SCH-202676 hydrobromide:

SCH-202676 在庫あり

Adenosine Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Adenosine A₁ receptor (A₁R) Adenosine A_2A receptor (A_2AR) Adenosine A_2B receptor (A_2BR) Adenosine A₃ receptor (A₃R)

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

分子量

348.26

分子式

C₁₅H₁₄BrN₃S

CAS 番号

265980-25-4

Appearance

Solid

Color

White to off-white

SMILES

[H]Br.C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 10 mg/mL (28.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8714 mL	14.3571 mL	28.7142 mL
5 mM	0.5743 mL	2.8714 mL	5.7428 mL
10 mM	0.2871 mL	1.4357 mL	2.8714 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.85%

Select Batch:

データシート (280 KB) SDS (252 KB)

COA (260 KB) HNMR (142 KB) RP-HPLC (226 KB) MS (69 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129. [Content Brief]

[2]. Lewandowicz AM, et al. The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. Br J Pharmacol. 2006 Feb;147(4):422-9. [Content Brief]

[3]. Fawzi A B, et al. SCH-202676: an allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors[J]. Molecular Pharmacology, 2001, 59(1): 30-37.

[4]. Gao ZG, et al. Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. Life Sci. 2004 May 7;74(25):3173-80. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8714 mL	14.3571 mL	28.7142 mL	71.7854 mL
	5 mM	0.5743 mL	2.8714 mL	5.7428 mL	14.3571 mL
	10 mM	0.2871 mL	1.4357 mL	2.8714 mL	7.1785 mL
	15 mM	0.1914 mL	0.9571 mL	1.9143 mL	4.7857 mL
	20 mM	0.1436 mL	0.7179 mL	1.4357 mL	3.5893 mL
	25 mM	0.1149 mL	0.5743 mL	1.1486 mL	2.8714 mL