2. Anti-infection GPCR/G Protein
  3. Influenza Virus G protein-coupled Bile Acid Receptor 1 Adenosine Receptor
  4. SCH-202676

SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM.

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SCH-202676

SCH-202676 Chemical Structure

CAS No. : 70375-43-8

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Based on 1 publication(s) in Google Scholar

Other Forms of SCH-202676:

SCH-202676 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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  • Purity & Documentation

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Description

SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 µM[1][2][3][4].

IC50 & Target[4]

Adenosine A3 receptor

 

In Vitro

SCH-202676 (compound 6a) (0.01-10 µM; 0, 5, 10 and 20 min) shows antiviral activity and inhibits 3CLpro in a time-dependent manner, with IC50 values of 0.409, 0.302, 0.206 and 0.191 µM for 0, 5, 10 and 20 min, respectively[1].
SCH-202676 (10 μM; 90 min) enhances the labelling of [35S]GTPγS in rat forebrain membranes[2].
SCH-202676 inhibits the agonist [3H]UK-14,304 (HY-B0659) and the antagonist [3H] Yohimbine (HY-12715) binding to the α2a adrenergic receptor[3].
SCH-202676 (10 μM) selectively accelerates agonist dissociation at adenosine A3 receptors, slows antagonist dissociation at adenosine Ai receptors, accelerates antagonist dissociation at adenosine AzA receptors[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SCH-202676 Related Antibodies
Molecular Weight

267.35

Formula

C15H13N3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

C/N=C1N=C(C2=CC=CC=C2)N(C3=CC=CC=C3)S/1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (374.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7404 mL 18.7021 mL 37.4041 mL
5 mM 0.7481 mL 3.7404 mL 7.4808 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7404 mL 18.7021 mL 37.4042 mL 93.5104 mL
5 mM 0.7481 mL 3.7404 mL 7.4808 mL 18.7021 mL
10 mM 0.3740 mL 1.8702 mL 3.7404 mL 9.3510 mL
15 mM 0.2494 mL 1.2468 mL 2.4936 mL 6.2340 mL
20 mM 0.1870 mL 0.9351 mL 1.8702 mL 4.6755 mL
25 mM 0.1496 mL 0.7481 mL 1.4962 mL 3.7404 mL
30 mM 0.1247 mL 0.6234 mL 1.2468 mL 3.1170 mL
40 mM 0.0935 mL 0.4676 mL 0.9351 mL 2.3378 mL
50 mM 0.0748 mL 0.3740 mL 0.7481 mL 1.8702 mL
60 mM 0.0623 mL 0.3117 mL 0.6234 mL 1.5585 mL
80 mM 0.0468 mL 0.2338 mL 0.4676 mL 1.1689 mL
100 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9351 mL
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SCH-202676 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH-20267670375-43-8SCH202676SCH 202676Influenza VirusG protein-coupled Bile Acid Receptor 1Adenosine ReceptorG-protein coupled receptor 19GPCR19TGR5GPBAR1P1 receptorAntiviral activity[35S]GTPγS[3H]UK-14,304[3H] YohimbineInhibitorinhibitorinhibit

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SCH-202676
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