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AIT

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By Targets:	Drug Derivative (1) Drug Isomer (1) Fungal (1) Interleukin Related (2) NOD-like Receptor (NLR) (1) PIKfyve (2) Reactive Oxygen Species (ROS) (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14644

Apilimod 35+ Cited Publications STA 5326; LAM-002A free base; AIT-101	Interleukin Related PIKfyve	Inflammation/Immunology Cancer
Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

HY-14644A

Apilimod mesylate 35+ Cited Publications STA 5326 mesylate; LAM-002A; AIT-101 mesylate	Interleukin Related PIKfyve	Inflammation/Immunology Cancer
Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

HY-N1459A

(S)-Campesterol 5-Ergosten-3β-ol	Drug Isomer	Others
(S)-Campesterol (5-Ergosten-3β-ol) is a phytosterol (terpenoid) found in the leaves of Plumeria rubra L., form acutifolia (Ait) Woodson .

HY-14644B

Apilimod hydrochloride STA 5326 hydrochloride; LAM-002A free base hydrochloride; AIT-101 hydrochloride	NOD-like Receptor (NLR)	Infection Inflammation/Immunology
Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.

HY-120251A

Leteprinim potassium AIT-082	Reactive Oxygen Species (ROS)	Neurological Disease
Leteprinim potassium (AIT-082), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim potassium is a hypoxanthine derivative neurotrophic agent. Leteprinim potassium can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim potassium reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim potassium increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species .

HY-120251

Leteprinim AIT-082 free acid	Reactive Oxygen Species (ROS)	Neurological Disease
Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species .

HY-RS13294

SLC5A8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLC5A8 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC5A8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLC5A8 Human Pre-designed siRNA Set A SLC5A8 Human Pre-designed siRNA Set A

HY-N2721

6'-O-Cinnamoyl-8-epikingisidic acid 6'-O-trans-cinnamoyl 8-epikingisidic acid	Others	Others
6'-O-Cinnamoyl-8-epikingisidic acid (6'-O-trans-cinnamoyl 8-epikingisidic acid) is a secoiridoid constituent isolated from the dried fruits of Ligustrum lucidum A_IT .

HY-N3414

Kushenol L	Others	Metabolic Disease
Kushenol L is one of the main components of EtOA cextracts from Kushen, a traditional medicinal herb derived from the dried roots of Sophora flavescens Ait. Kushenol L is a flavonoid and plays an important role in anti-diabeticeffects .

HY-N12606

Neodidymelliosides A	Fungal	Infection
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candida albicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .

HY-N0109A

(S)-Salidroside	Drug Derivative	Others
(S)-Salidroside is a tyrosine-derived phenylethanoid glycoside natural product .

(S)-Campesterol 5-Ergosten-3β-ol	Structural Classification Bursera simaruba (L.) Sarg. Plants Burseraceae Steroids Source Classification	Drug Isomer
(S)-Campesterol (5-Ergosten-3β-ol) is a phytosterol (terpenoid) found in the leaves of Plumeria rubra L., form acutifolia (Ait) Woodson .

6'-O-Cinnamoyl-8-epikingisidic acid 6'-O-trans-cinnamoyl 8-epikingisidic acid	Classification of Application Fields Oleaceae Simple Phenylpropanols Ligustrum lucidum Ait. Other Diseases Phenylpropanoids Plants Disease Research Fields Source Classification	Others
6'-O-Cinnamoyl-8-epikingisidic acid (6'-O-trans-cinnamoyl 8-epikingisidic acid) is a secoiridoid constituent isolated from the dried fruits of Ligustrum lucidum A_IT .

Kushenol L	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Others
Kushenol L is one of the main components of EtOA cextracts from Kushen, a traditional medicinal herb derived from the dried roots of Sophora flavescens Ait. Kushenol L is a flavonoid and plays an important role in anti-diabeticeffects .

Neodidymelliosides A	Microorganisms Saccharides Monosaccharides Source Classification	Fungal
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candida albicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .

(S)-Salidroside	Structural Classification Monophenols Oleaceae Ligustrum lucidum Ait. Phenols Plants Source Classification	Drug Derivative
(S)-Salidroside is a tyrosine-derived phenylethanoid glycoside natural product .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703394

	SLC5A8 Protein, Human (HEK293) AIT; SMCT; SMCT1	Human	HEK293
	SLC5A8 Protein, Human (HEK293) is the recombinant human-derived SLC5A8, expressed by HEK293 , with tag Free labeled tag. ,

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SLC5A8 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SLC5A8 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC5A8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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AIT

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Recombinant Proteins

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