Aquaporin+4

By Targets:	Aquaporin (7) Amyloid-β (3) Bacterial (2) Dihydroorotate Dehydrogenase (2) ERK (1) Ferroptosis (2) Glutathione Peroxidase (2) Heme Oxygenase (HO) (2) Insecticide (2) Keap1-Nrf2 (2) NF-κB (2) PAI-1 (2) PROTAC Linkers (2) Proton Pump (2) Reference Standards (1) Thrombin (2) Toll-like Receptor (TLR) (2) TRP Channel (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (6) Neurological Disease (7)

Targets Recommended: Aquaporin

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-W008574

TGN-020 Maximum Cited Publications 21 Publications Verification	PROTAC Linkers	Inflammation/Immunology Cancer
TGN-020 is a selective **Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker** that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats ^[4].

HY-W176557

TGN-073	Aquaporin Amyloid-β	Neurological Disease
TGN-073 is an orally active, blood-brain barrier-permeable aquaporin 4 *(AQP4)* modulator. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid β-40 and β-42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain .

HY-W008574A

TGN-020 sodium Maximum Cited Publications 21 Publications Verification	PROTAC Linkers	Inflammation/Immunology Cancer
TGN-020 sodium is a selective **Aquaporin 4 (AQP4) inhibitor with an IC₅₀ of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker** that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats ^[4].

HY-115460

AER-271 1 Publications Verification	Aquaporin	Cardiovascular Disease Neurological Disease
AER-271, a phosphonate proagent derivative of AER-270, is an *aquaporin-4* (AQP4) inhibitor for the research of acute ischemic stroke .

HY-N3097

Pellitorine	TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of *RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4* and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria ^[4] .

HY-P10937

AQP4 (205-215)	Aquaporin	Inflammation/Immunology
AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .

HY-P10937A

AQP4 (205-215) TFA	Aquaporin	Inflammation/Immunology
AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .

HY-N3097R

Pellitorine (Standard)	Reference Standards TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of *RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4* and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.

HY-18805

Nicotinanilide N-Phenylnicotinamide	Aquaporin	Neurological Disease
Nicotinanilide (N-Phenylnicotinamide) (Compound 12) is an *aquaporin 4* (AQP4) inhibitor. Nicotinanilide can be used for research on diseases associated with AQP4 dysfunction, such as epilepsy and migraine .

HY-W017091

3-Phenoxy-1,2-propanediol	Aquaporin	Neurological Disease
3-Phenoxy-1,2-propanediol (compound 15) is a weak **aquaporin 4 (AQP4)** inhibitor . 3-Phenoxy-1,2-propanediol is an important intermediate for pharmaceuticals .

HY-P991869

Aquaporumab AQmabAM; rAb-53	Aquaporin	Neurological Disease
Aquaporumab (AQmabAM) is an engineered human monoclonal IgG antibody. Aquaporumab is a selective inhibitor of aquaporin 4 (AQP4), binding tightly to AQP4 and competitively displacing AQP4-IgG from serum [1][2]. Aquaporumab significantly reduces neuromyelitis optica lesions in spinal cord slice cultures and in mice receiving intracerebral injection of AQP4-IgG and complement [1][2]. Aquaporumab can be used for research on neuromyelitis optica spectrum disorders [1][2]."}

Cat. No.	Nombre del producto	Target	Research Area

HY-P10937

AQP4 (205-215)	Aquaporin	Inflammation/Immunology
AQP4 (205-215) is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .

HY-P10937A

AQP4 (205-215) TFA	Aquaporin	Inflammation/Immunology
AQP4 (205-215) TFA is a fragment of Aquaporin-4 (AQP4). AQP4 is a neuromyelitis optica autoantigen that is upregulated and presented in B cells after engagement of CD40. AQP4 is associated with autoimmune inflammatory diseases of the central nervous system (CNS), neuromyelitis optica (NMO) .

Cat. No.	Nombre del producto	Target	Research Area	Image

HY-P991869

Aquaporumab AQmabAM; rAb-53	Aquaporin	Neurological Disease
Aquaporumab (AQmabAM) is an engineered human monoclonal IgG antibody. Aquaporumab is a selective inhibitor of aquaporin 4 (AQP4), binding tightly to AQP4 and competitively displacing AQP4-IgG from serum [1][2]. Aquaporumab significantly reduces neuromyelitis optica lesions in spinal cord slice cultures and in mice receiving intracerebral injection of AQP4-IgG and complement [1][2]. Aquaporumab can be used for research on neuromyelitis optica spectrum disorders [1][2]."}

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N3097

Pellitorine	Alkaloids Classification of Application Fields Other Alkaloids Piperaceae Plants Disease Research Fields Piper nigrum Linn. Biological Pesticide Research Source Classification Cancer Agricultural Research	TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB ERK Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial
Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of *RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4* and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria ^[4] .

HY-N3097R

Pellitorine (Standard)	Alkaloids Other Alkaloids Piperaceae Plants Piper nigrum Linn. Source Classification	Reference Standards TRP Channel Amyloid-β Toll-like Receptor (TLR) Keap1-Nrf2 Heme Oxygenase (HO) Dihydroorotate Dehydrogenase Ferroptosis PAI-1 NF-κB Proton Pump Glutathione Peroxidase Thrombin Insecticide Bacterial
Pellitorine (Standard) is the analytical standard of Pellitorine (HY-N3097). Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of *RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4* and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H⁺-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria.

HY-W017091

3-Phenoxy-1,2-propanediol	Structural Classification Productos naturales Plants Source Classification	Aquaporin
3-Phenoxy-1,2-propanediol (compound 15) is a weak **aquaporin 4 (AQP4)** inhibitor . 3-Phenoxy-1,2-propanediol is an important intermediate for pharmaceuticals .

Species:	Human (2) Mouse (2)
Tag:	SUMO (1) His (3) Tag Free (1)
Source:	E. coli Cell-free (2) E. coli (2)

Cat. No.	Compare	Nombre del producto	Species	Source	Image

HY-P702215

	AQP4 Protein, Mouse (Cell-Free) Aquaporin-4; Mercurial-insensitive water channel; MIWC; WCH4	Mouse	E. coli Cell-free
	The AQP4 protein forms water-specific channels that are critical for brain water homeostasis and lymphoid solute transport. It regulates water exchange at the blood-brain interface, promoting the influx of cerebrospinal fluid into the brain and the drainage of interstitial fluid. AQP4 Protein, Mouse (Cell-Free) is the recombinant mouse-derived AQP4 protein, expressed by E. coli Cell-free , with tag free.

HY-P702216

	AQP4 Protein, Mouse (Cell-Free, His) Aquaporin-4; Mercurial-insensitive water channel; MIWC; WCH4	Mouse	E. coli Cell-free
	The AQP4 protein forms water-specific channels that are critical for brain water homeostasis and lymphoid solute transport. It regulates water exchange at the blood-brain interface, promoting the influx of cerebrospinal fluid into the brain and the drainage of interstitial fluid. AQP4 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived AQP4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P72087A

	AQP4 Protein, Human (His) AQP 4; AQP-4; AQP4; AQP4_HUMAN; Aquaporin type 4; Aquaporin-4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; Mercurial-insensitive water channel; MGC22454; MIWC; WCH 4; WCH4	Human	E. coli
	The AQP4 protein forms water-specific channels and is involved in brain water balance and solute transport. AQP4 Protein, Human (His) is the recombinant human-derived AQP4, expressed by E. coli, with N-6His labeled tag. The total length of AQP4 Protein, Human (His) is 71 a.a.*.

HY-P72087

	AQP4 Protein, Human (His-SUMO) AQP 4; AQP-4; AQP4; AQP4_HUMAN; Aquaporin type 4; Aquaporin-4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; Mercurial-insensitive water channel; MGC22454; MIWC; WCH 4; WCH4	Human	E. coli
	The AQP4 protein forms water-specific channels and is involved in brain water balance and solute transport. AQP4 Protein, Human (His-SUMO) is the recombinant human-derived AQP4 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (3) Mouse (2)
Application:	IHC-P (3) ICC/IF (2) IHC-F (1) WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Nombre del producto	Application	Reactivity	Image

HY-P83459A

	Aquaporin 4 Antibody aquaporin 4; WCH4; Mercurial-insensitive water channel; MIWC; AQP 4; AQP4; Aquaporin4; HMIWC 2; HMIWC2; Mercurial insensitive water channel; MGC22454; MIWC; AQP4_HUMAN; Aquaporin-4; AQP-4.	WB, IHC-P, IHC-F, FC, ICC/IF	Human, Mouse, Rat
	Aquaporin 4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Aquaporin 4.

HY-P85657

	Aquaporin 4 Antibody (YA5349) AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Aquaporin 4 Antibody (YA5349) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Aquaporin 4.

HY-P83459

	Aquaporin 4 Antibody (YA3204) AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4	IHC-P	Human, Rat
	Aquaporin 4 Antibody (YA3204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 4.

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Aquaporin+4

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