40 Results for "

BH3 peptide

" in MedChemExpress (MCE) Product Catalog:
Products (40)

40 Results for "BH3 peptide" in MCE Product Catalog:

19
19 Publications Verification
Cat. No.: HY-12048
CAS No.: 3895-92-9
Purity:  99.11%
Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
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1
1 Cited Publications
Cat. No.: HY-P1527
CAS No.: 505070-06-4
Target:  

Bcl-2 Family

Research Areas:  

Others

Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.)
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Cat. No.: HY-P1889
CAS No.: 721885-31-0
Target:  

Bcl-2 Family

Research Areas:  

Inflammation/Immunology

Bim BH3, Peptide IV is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins .
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Cat. No.: HY-N2359
CAS No.: 34316-15-9
Chelerythrine is an alkaloid, acts as a potent and selective Ca 2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM. Chelerythrine triggers Apoptosis and Autophagy. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine shows antibacterial activities against Gram-positive bacteria, Staphylococcus aureus (SA), MRSA .
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Cat. No.: HY-100383
CAS No.: 300817-68-9
Purity:  ≥98.0%
Synonyms: BHI1
Research Areas:  

Cancer

BH3I-1 is a Bcl-2 family antagonist, which inhibits the binding of the Bak BH3 peptide to Bcl-xL with a Ki of 2.4±0.2 μM in FP assay. BH3I-1 has a Kd of 5.3 μM against the p53/MDM2 pair.
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Cat. No.: HY-P5328
CAS No.: 505070-09-7
Target:  

NADPH Oxidase

Research Areas:  

Others

Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
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Cat. No.: HY-P2343
Target:  

Apoptosis

Research Areas:  

Cancer

BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .
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Cat. No.: HY-P10614
CAS No.: 300349-78-4
Target:  

Apoptosis Bcl-2 Family

Research Areas:  

Cancer

Bid BH3 peptide is a pro-apoptotic peptide derived from the Bid protein. Through its α-helical conformation, Bid BH3 peptide inserts into the hydrophobic grooves of anti-apoptotic Bcl-2 family proteins (Bcl-xl, Bcl-2, Bcl-w and Bax), competitively displaces and releases the pro-apoptotic proteins Bax/Bak, thereby initiating mitochondrial outer membrane permeabilization (MOMP) and the caspase cascade for apoptosis. Bid BH3 peptide can be used in cancer-related research .
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Cat. No.: HY-P5342
Target:  

Bcl-2 Family

Research Areas:  

Others

Hrk BH3 is a biological active peptide. (BH3 domain of Hrk)
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Cat. No.: HY-P1562
Target:  

Bcl-2 Family

Research Areas:  

Cancer

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.
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Cat. No.: HY-P2499A
Target:  

Bcl-2 Family

Research Areas:  

Cancer

BAD (103-127) (human), FAM-labeled TFA is a FAM-labeled human BAD (103-127) (HY-P2468). BAD (103-127) (human) TFA, the 25-mer Bad peptide, is derived from the BH3 domain of BAD and can antagonize the function of Bcl-xL .
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Cat. No.: HY-P2468
CAS No.: 331762-68-6
Synonyms: BADBH3 103-127 (human); BADBH3 (human)
Target:  

Bcl-2 Family

Research Areas:  

Cancer

BAD (103-127) (human), the 25-mer Bad peptide, is derived from the BH3 domain of BAD, can antagonize the function of Bcl-xL. BAD (103-127) (human) is reported to have almost 800-fold higher affinity for Bcl-XL than the 16-mer peptide .
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Cat. No.: HY-P2466
CAS No.: 299946-20-6
Target:  

Apoptosis

Research Areas:  

Cancer

Bax BH3 peptide (55-74), wild type is a 20-amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models .
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Cat. No.: HY-P1889A
Target:  

Bcl-2 Family

Research Areas:  

Inflammation/Immunology

Bim BH3, Peptide IV TFA is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins .
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Cat. No.: HY-P5325A
Target:  

Bcl-2 Family

Research Areas:  

Others

Bid BH3 (80-99) acetate is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
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Cat. No.: HY-P5325
CAS No.: 505070-05-3
Target:  

Bcl-2 Family

Research Areas:  

Others

Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
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Cat. No.: HY-P10614A
Target:  

Apoptosis Bcl-2 Family

Research Areas:  

Cancer

Bid BH3 peptide acetate is a pro-apoptotic peptide derived from the Bid protein. Through its α-helical conformation, Bid BH3 peptide inserts into the hydrophobic grooves of anti-apoptotic Bcl-2 family proteins (Bcl-xl, Bcl-2, Bcl-w and Bax), competitively displaces and releases the pro-apoptotic proteins Bax/Bak, thereby initiating mitochondrial outer membrane permeabilization (MOMP) and the caspase cascade for apoptosis. Bid BH3 peptide acetate can be used in cancer-related research .
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Cat. No.: HY-P11374
Target:  

Bcl-2 Family Apoptosis

Research Areas:  

Cancer

Bid BH3-Gly-r8 is Bid BH3 linked to eight arginine residues. Bid BH3-Gly-r8 shows no difference in apoptotic effects compared to its unmodified peptide homologue. Bid BH3 has high affinity for Bax and Bcl-2. Bid BH3-Gly-r8 can be used in the research of tumors .
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Cat. No.: HY-123244
CAS No.: 810659-53-1
Target:  

Bcl-2 Family Apoptosis

Research Areas:  

Cancer

YC137 is a potent Bcl-2 antagonist with Kis of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research .
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Cat. No.: HY-P5341
CAS No.: 505070-08-6
Target:  

Bcl-2 Family

Research Areas:  

Others

Bik BH3 is a biological active peptide. (BH3 domain of BIK)
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