2. Apoptosis
  3. Bcl-2 Family
  4. Icterogenin

Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development.

For research use only. We do not sell to patients.

Icterogenin

Icterogenin Chemical Structure

CAS No. : 561-47-7

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Icterogenin Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Description

Icterogenin is a selective inhibitor targeting the Bcl-XL/Bak BH3 domain peptide interaction and exhibits anti-leukemic activity. Icterogenin regulates protein interactions and affects tumor cell survival. Icterogenin is an oleanane-type triterpenoid compound that can be isolated from Lantana camara and is useful in the field of anti-tumor drug development[1].

IC50 & Target

Bcl-xL

 

In Vitro

Icterogenin exhibits cytotoxicity against HL-60 human promyelocytic leukemia cells, with IC50 values ranging from 1.16 to 68.4 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Icterogenin Related Antibodies
Molecular Weight

568.78

Formula

C35H52O6
CAS No.
SMILES

OC([C@@]([C@@H](C1)OC(/C(C)=C\C)=O)(CC[C@]23C)[C@](CC1(C)C)([H])C2=CC[C@@]4([H])[C@]3(CC[C@]([C@](C)5CO)([H])[C@@]4(CCC5=O)C)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Icterogenin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Icterogenin561-47-7Bcl-2 FamilyInhibitorinhibitorinhibit

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