Two new triterpenoids from the leaves and stems of Lantana camara

  • Nat Prod Res. 2021 Nov;35(21):3757-3765. doi: 10.1080/14786419.2020.1736063.
Masateru Ono  1 ,  Asami Hashimoto  1 ,  Mayu Miyajima  1 ,  Aimi Sakata  1 ,  Chisato Furusawa  1 ,  Mizuki Shimode  1 ,  Shuhei Tsutsumi  1 ,  Shin Yasuda  1 ,  Masafumi Okawa  2 ,  Junei Kinjo  2 ,  Hitoshi Yoshimitsu  3 ,  Toshihiro Nohara  3
Affiliations
  • 1. School of Agriculture, Tokai University, Kumamoto, Japan.
  • 2. Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
  • 3. Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
PMID: 32141312 DOI: 10.1080/14786419.2020.1736063
Abstract

Two new oleanane-type triterpenoids with an epoxy bridge between C-3 and C-25, named lantacamaric acids A and B, were isolated from the leaves and stems of Lantana camara L. (Verbenaceae). In addition, seven known triterpenoids, two known iridoid glycosides, four known phenylethanoid glycosides, one known flavonoid glycoside, and one known cyanogenic glycoside were isolated. Their structures were determined based on the spectroscopic data. Furthermore, the cytotoxic activities of the isolated triterpenoids toward HL-60 cells were examined. The IC50 values of all compounds were obtained and ranged from 1.16 to 68.4 μM, with three compounds exhibiting stronger activities than the positive control, cisplatin. In addition, the structure-activity relationship was investigated.

Keywords
Lantana camara; Vabenaceae; cytotoxic activity; lantacamaric acid; oleanane-type triterpenoid.
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