YC137
YC137 is a potent Bcl-2 antagonist with Kis of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research.
For research use only. We do not sell to patients.
- CAS No.: 810659-53-1
- Formula: C24H21N3O6S2
- Molecular Weight:511.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Bcl-2 1.3 μM (Ki) |
Bcl-xL >100 μM (Ki) |
Chemical Information
-
CAS No. 810659-53-1
-
Molecular Weight 511.57
-
Formula C24H21N3O6S2
-
SMILES
CSCC[C@@H](C(OC1=CC=C(NC2=NC(C3=O)=C(C(C4=C3C=CC=C4)=O)S2)C=C1)=O)NC(OC)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. YC137 was solubilized at 10 mmol/L in dimethylsulfoxide and kept at 20°C in the dark until use. [Content Brief]
[2]. Rie Nishi, et al. Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line. Cancer Sci. 2013 Apr;104(4):502-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz