810659-53-1
Chemical Structure
YC137
- CAS No.: 810659-53-1
- Formula:C24H21N3O6S2
- Molecular Weight:511.57
IUPAC Name: 4-((4,9-dioxo-4,9-dihydronaphtho[2,3-d]thiazol-2-yl)amino)phenyl (methoxycarbonyl)-L-methioninate
InChIKey: SFDSXIZFOOBDMC-KRWDZBQOSA-N
SMILES: CSCC[C@@H](C(OC1=CC=C(NC2=NC(C3=O)=C(C(C4=C3C=CC=C4)=O)S2)C=C1)=O)NC(OC)=O
Biological Activity: YC137 is a potent Bcl-2 antagonist with Kis of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research[1][2].
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YC137 | YC137 is a potent Bcl-2 antagonist with Kis of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research. | |||||||||||||||||||||
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References
- [1]. YC137 was solubilized at 10 mmol/L in dimethylsulfoxide and kept at 20°C in the dark until use. [Content Brief]
- [2]. Rie Nishi, et al. Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line. Cancer Sci. 2013 Apr;104(4):502-7. [Content Brief]
