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Results for "

CMS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) Apoptosis (2) Autophagy (2) CDK (1) Drug Intermediate (1) Histone Methyltransferase (1) HIV (1) Ligands for E3 Ligase (1) Liposome (1) Molecular Glues (1) Na+/H+ Exchanger (NHE) (2) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (2) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Phospholipids (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135981

CMS-121 2 Publications Verification	Acetyl-CoA Carboxylase	Neurological Disease Inflammation/Immunology
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC₅₀ values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .

HY-139065

AMPC	Apoptosis	Cancer
AMPC is a potent and effective TFF3 inhibitor. AMPC inhibits cell proliferation, survival, oncogenicity, and CSC-like behaviour in TFF3-positive CMS4 CRC cells. AMPC acts as a potential anti-cancer agent alone or in combination with 5-FU, and can be used for cancer research .

HY-W181530

NCT02	Molecular Glues CDK Apoptosis Ligands for E3 Ligase	Cancer
NCT02 is a molecular glue degrader based on the E3 ubiquitin ligase DDB1 that targets CDK12 and its binding partner CCNK. NCT02 triggers the ubiquitination and proteasomal degradation of CCNK, thereby downregulating CDK12 protein levels and inhibiting its downstream signaling pathways. NCT02 can induce tumor cell apoptosis, arrest the cell cycle, and selectively inhibit the proliferation of colorectal cancer cells carrying TP53 defects or belonging to the consensus molecular subtype *CMS4*. NCT02 has the potential to inhibit tumor growth in in vitro and in vivo models .

HY-142980

DOPG Dioleoylphosphatidylglycerol	Liposome	Inflammation/Immunology
DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion .

HY-18071

BI-9627 3 Publications Verification	Na+/H+ Exchanger (NHE) Autophagy	Cardiovascular Disease
BI-9627, a chemical probe, is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC₅₀ = 6 and 31 nM in intracellular pH recovery (pH_i) and human platelet swelling assays). BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pH_i of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca ²⁺ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-18071A

BI-9627 hydrochloride 3 Publications Verification	Na+/H+ Exchanger (NHE) Autophagy	Cardiovascular Disease
BI-9627 hydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC₅₀ = 6 and 31 nM in intracellular pH recovery (pH_i) and human platelet swelling assays). BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride decreases autophagy in HTR-8/SVneo cells. BI-9627 hydrochloride can significantly reduce the pH_i of human sperm and partially reverse the effect of DMA. BI-9627 hydrochloride prolongs Ca ²⁺ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-150759

HIV-1 inhibitor-45	HIV	Infection
HIV-1 inhibitor-45 is a potent HIV-1 RNase H inhibitor with an IC₅₀ value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity. HIV-1 inhibitor-45 shows poor cell permeability (with an apparent permeability coefficient (P_app) lower than 0.48 × 10 ⁻⁶ cm/s) .

HY-RS02224

CD2AP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD2AP Human Pre-designed siRNA Set A contains three designed siRNAs for CD2AP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD2AP Human Pre-designed siRNA Set A CD2AP Human Pre-designed siRNA Set A

HY-139995

Spermine Prodrug-1	Drug Intermediate	Others
Spermine precursor-1 (Compound 1) is a redox-sensitive spermine precursor for the potential research of snyder robinson syndrome. Spermine precursor-1 inhibits wild-type (CMS-24949) and spermine synthase gene (SMS) mutant (CMS-26559, and CMS-6233) fibroblast cells with IC₅₀s of 326.7, 198.5, and 244.1 μM, respectively .

HY-168497

C-MS023	Histone Methyltransferase	Cancer
C-MS023 is a photo-activatable MS023 (HY-19615) prodrug, achieving spatiotemporal inhibition of Histone Arginine Asymmetric Dimethylation. C-MS023 inhibits PRMT6 mediated asymmetric dimethylation of H3 arginine 2 (H3R2me2a), with an estimate IC₅₀ of 0.2224 μM. The photolysis of C-MS023 could be triggered by visible light irradiation at 420 nm, thereby liberating MS023 for effective downregulation of histone arginine asymmetric dimethylation and DNA replication-related transcriptomic activities .

HY-RS28027

Cd2ap Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cd2ap Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd2ap gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd2ap Rat Pre-designed siRNA Set A Cd2ap Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-142980

DOPG Dioleoylphosphatidylglycerol	Biochemical Assay Reagents
DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion .

DOPG

Dioleoylphosphatidylglycerol

Biochemical Assay Reagents

DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion .

Species:	Human (4)
Tag:	His (4) GST (1) Trx (1)
Source:	Sf9 insect cells (1) P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72139

	CHRNA1 Protein, Human (His) Acetylcholine receptor subunit alpha; ACHA_HUMAN; AChR; ACHRA; ACHRD; CHNRA; Cholinergic receptor nicotinic alpha 1 subunit; Cholinergic receptor nicotinic alpha polypeptide 1; Cholinergic receptor; nicotinic; alpha polypeptide 1 muscle; ; Chrna1; CMS1A; CMS1B; CMS2A; FCCMS; Nicotinic cholinergic receptor alpha 1; SCCMS; Schizophrenia neurophysiologic defect candidate	Human	E. coli
	The CHRNA1 Protein undergoes a substantial conformational shift upon acetylcholine binding, influencing all subunits and leading to the activation of an ion-conducting channel. Yet, the acetylcholine receptor alpha subunit of CHRNA1 can be non-functional in certain cases, underscoring the need to comprehend the factors governing its functionality and integration into fully operational acetylcholine-gated cation-selective channels. CHRNA1 Protein, Human (His) is the recombinant human-derived CHRNA1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72140

	CHRNA1 Protein, Human (His-Trx) Acetylcholine receptor subunit alpha; ACHA_HUMAN; AChR; ACHRA; ACHRD; CHNRA; Cholinergic receptor nicotinic alpha 1 subunit; Cholinergic receptor nicotinic alpha polypeptide 1; Cholinergic receptor; nicotinic; alpha polypeptide 1 muscle; Chrna1; CMS1A; CMS1B; CMS2A; FCCMS; Nicotinic cholinergic receptor alpha 1; SCCMS; Schizophrenia neurophysiologic defect candidate	Human	E. coli
	The CHRNA1 Protein undergoes a substantial conformational shift upon acetylcholine binding, influencing all subunits and leading to the activation of an ion-conducting channel. Yet, the acetylcholine receptor alpha subunit of CHRNA1 can be non-functional in certain cases, underscoring the need to comprehend the factors governing its functionality and integration into fully operational acetylcholine-gated cation-selective channels. CHRNA1 Protein, Human (His-Trx) is the recombinant human-derived CHRNA1 protein, expressed by E. coli , with N-Trx, N-6*His labeled tag.

HY-P72273

	MUSK Protein, Human (P.pastoris, His) Muscle, skeletal receptor tyrosine-protein kinase; CMS9; FADS; MDK4; Muscle; MuSK;	Human	P. pastoris
	MUSK protein is a receptor tyrosine kinase that plays a crucial role in the formation and maintenance of the neuromuscular junction (NMJ). After LRP4 recruits AGRIN, MUSK phosphorylates and activates, affecting gene expression, coordinating actin cytoskeletal reorganization, and clustering acetylcholine receptors (AChR) in the postsynaptic membrane. MUSK Protein, Human (P.pastoris, His) is the recombinant human-derived MUSK protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P702701

	MUSK Protein, Human (Active, sf9, His, GST) MUSK; muscle associated receptor tyrosine kinase; CMS9; FADS; FADS1	Human	Sf9 insect cells
	MUSK protein is a receptor tyrosine kinase that plays a crucial role in the formation and maintenance of the neuromuscular junction (NMJ). After LRP4 recruits AGRIN, MUSK phosphorylates and activates, affecting gene expression, coordinating actin cytoskeletal reorganization, and clustering acetylcholine receptors (AChR) in the postsynaptic membrane. MUSK Protein, Human (sf9, His, GST) is the recombinant human-derived MUSK, expressed by Sf9 insect cells, with His, GST labeled tag.

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Species
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Tag
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Gene ID
Molecular Weight
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Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (8) Rabbit (8)
Reactivity:	Human (15) Mouse (8) Rat (10) Monkey (2) Hamster (2)
Application:	IHC-P (8) ICC/IF (6) IF-Tissue (1) IP (6) IHC-F (2) WB (14) FC (10) ELISA (6)
Isotype:	IgG (8) IgG1 (8)
Conjugation:	Non-conjugated (16)
Clonality:	Monoclonal (8) Recombinant (3)
Modification:	Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84484

	CHRNE Antibody (YA4181) ACHRE; CMS1D; CMS1E; CMS2A; CMS4A; CMS4B; CMS4C; FCCMS; SCCMS	WB, FC, ELISA	Human, Rat
	CHRNE Antibody (YA4181) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHRNE.

HY-P84484A

	CHRNE Antibody (YA4181)(PBS only) ACHRE; CMS1D; CMS1E; CMS2A; CMS4A; CMS4B; CMS4C; FCCMS; SCCMS	WB, FC, ELISA	Human, Rat
	CHRNE Antibody (YA4181) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHRNE.

HY-P84502

	CHRND Antibody (YA4199) ACHRD; CMS2A; CMS3A; CMS3B; CMS3C; FCCMS; SCCMS	WB, FC, ELISA	Human
	CHRND Antibody (YA4199) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHRND.

HY-P84502A

	CHRND Antibody (YA4199)(PBS only) ACHRD; CMS2A; CMS3A; CMS3B; CMS3C; FCCMS; SCCMS	WB, FC, ELISA	Human
	CHRND Antibody (YA4199) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CHRND.

HY-P88261

	DOK7 Antibody (YA7945) C4orf25; CMS1B; CMS10	IHC-P, ICC/IF, FC	Human, Mouse
	DOK7 Antibody (YA7945) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DOK7.

HY-P88261A

	DOK7 Antibody (YA7945)(PBS only) C4orf25; CMS1B; CMS10	IHC-P, ICC/IF, FC	Human, Mouse
	DOK7 Antibody (YA7945) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DOK7.

HY-P83430

	PPCEL Antibody (YA3175) CMS22; Prolylendopeptidase-like	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
	PPCEL Antibody (YA3175) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPCEL.

HY-P83430A

	PPCEL Antibody (YA3175)(PBS only) CMS22; Prolylendopeptidase-like	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
	PPCEL Antibody (YA3175) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPCEL.

HY-P81100

	ChAT Antibody Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN.	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	ChAT Antibody is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ChAT.

HY-P86678

	CHAT Antibody (YA6370) Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Mouse, Rat
	CHAT Antibody (YA6370) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CHAT.

HY-P810601

	Choline Acetyltransferase Antibody (YA9864) Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN.	WB, IHC-F	Human, Mouse, Rat
	Choline Acetyltransferase Antibody (YA9864) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Choline Acetyltransferase.

HY-P810602

	Choline Acetyltransferase Antibody (YA9865) Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN.	WB, IP, ICC/IF, FC	Human, Mouse, Rat
	Choline Acetyltransferase Antibody (YA9865) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Choline Acetyltransferase.

HY-P83167

	GFPT1 Antibody (YA2912) GFA; GFAT; GFPT; MSLG; CMS12; GFAT1; CMSTA1; GFAT 1; GFAT1m; GFPT1L	WB, IHC-P, IP	Human
	GFPT1 Antibody (YA2912) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GFPT1.

HY-P84494

	GFPT1 Antibody (YA4191) GFA; GFAT; GFPT; MSLG; CMS12; GFAT1; CMSTA1; GFAT 1; GFAT1m; GFPT1L	WB, ICC/IF, FC, ELISA	Human, Rat, Monkey
	GFPT1 Antibody (YA4191) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GFPT1.

HY-P83167A

	GFPT1 Antibody (YA2912)(PBS only) GFA; GFAT; GFPT; MSLG; CMS12; GFAT1; CMSTA1; GFAT 1; GFAT1m; GFPT1L	WB, IHC-P, IP	Human
	GFPT1 Antibody (YA2912) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GFPT1.

HY-P84494A

	GFPT1 Antibody (YA4191)(PBS only) GFA; GFAT; GFPT; MSLG; CMS12; GFAT1; CMSTA1; GFAT 1; GFAT1m; GFPT1L	WB, ICC/IF, FC, ELISA	Human, Rat, Monkey
	GFPT1 Antibody (YA4191) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GFPT1.

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Cat. No.	Product Name		Classification

HY-142980

DOPG Dioleoylphosphatidylglycerol		Phospholipids
DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion .

HY-RS02224

CD2AP Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CD2AP Human Pre-designed siRNA Set A contains three designed siRNAs for CD2AP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28027

Cd2ap Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cd2ap Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd2ap gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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