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AMPC 

Cat. No.: HY-139065
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AMPC is a potent and effective TFF3 inhibitor. AMPC inhibits cell proliferation, survival, oncogenicity, and CSC-like behaviour in TFF3-positive CMS4 CRC cells. AMPC acts as a potential anti-cancer agent alone or in combination with 5-FU, and can be used for cancer research.

For research use only. We do not sell to patients.

AMPC Chemical Structure

AMPC Chemical Structure

CAS No. : 2254434-33-6

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Description

AMPC is a potent and effective TFF3 inhibitor. AMPC inhibits cell proliferation, survival, oncogenicity, and CSC-like behaviour in TFF3-positive CMS4 CRC cells. AMPC acts as a potential anti-cancer agent alone or in combination with 5-FU, and can be used for cancer research[1].

In Vitro

AMPC decreases cell proliferation in CMS4 CRC cells, the IC50 values are 2.63 μM, 4.65 μM, and 69.69 μM, respectively in SW620 (high TFF3 expression), Caco-2, SW480 cells (low TFF3 expression), respectively[1].
AMPC (1-10 μM) significantly reduces the total cellular levels of TFF3 in SW620 and Caco2 cells in a dose dependent manner[1].
AMPC induces apoptosis in a dose dependent manner by the inhibition of TFF3, it induces a decrease in the S-phase population and increases caspase3/7 activity compared with control cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AMPC (intraperitoneal injection; 40 mg/kg; once daily) leads to a significant reduction of tumour volume in AMPC-treated mice as compared to vehicle-treated mice from day 11 onward. AMPC results in larger areas of tumour necrosis and increased area of cells with apoptotic features in SW620 tumours. AMPC also significantly reduces tumour and serum TFF3 levels in vivo.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SW620 cells are subcutaneously injected into nude mice[1]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; 40 mg/kg; once daily
Result: Lead to tumor decreasein vivo.
Results in a marked reduction of Ki67 expression in tumor.
Molecular Weight

425.41

Formula

C₂₅H₁₆FN₃O₃

CAS No.
SMILES

N#CC(C1C2=CC=C(C3=CC(C)=C(F)N=C3)C=C2)=C(N)OC(C4=CC=CC=C4O5)=C1C5=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AMPCOthersTFF3CMS4 CRCcancertumorSW620Inhibitorinhibitorinhibit

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