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Cat. No.: HY-139995

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Spermine Prodrug-1

Spermine precursor-1 (Compound 1) is a redox-sensitive spermine precursor for the potential research of snyder robinson syndrome. Spermine precursor-1 inhibits wild-type (CMS-24949) and spermine synthase gene (SMS) mutant (CMS-26559, and CMS-6233) fibroblast cells with IC₅₀s of 326.7, 198.5, and 244.1 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 2576358-68-2
Formula: C₂₄H₄₅Cl₃N₄O₅
Molecular Weight:576.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Spermine Prodrug-1 Chemical Structure

CAS No.: 2576358-68-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	IC₅₀	>500 μM Compound: 1	Cytotoxicity against SMS mutant human CMS-23916 cells in presence of aminoguanidine measured after 72 hrs Cytotoxicity against SMS mutant human CMS-23916 cells in presence of aminoguanidine measured after 72 hrs	[PMID: 34695351]
Fibroblast	IC₅₀	198.5 μM Compound: 1	Cytotoxicity against SMS mutant human CMS-26559 cells in presence of aminoguanidine measured after 72 hrs Cytotoxicity against SMS mutant human CMS-26559 cells in presence of aminoguanidine measured after 72 hrs	[PMID: 34695351]
Fibroblast	IC₅₀	22.1 μM Compound: 1	Cytotoxicity against SMS mutant human CMS-26559 cells in absence of aminoguanidine measured after 72 hrs Cytotoxicity against SMS mutant human CMS-26559 cells in absence of aminoguanidine measured after 72 hrs	[PMID: 34695351]
Fibroblast	IC₅₀	244 μM Compound: 1	Cytotoxicity against SMS mutant human CMS-6233 cells in presence of aminoguanidine measured after 72 hrs Cytotoxicity against SMS mutant human CMS-6233 cells in presence of aminoguanidine measured after 72 hrs	[PMID: 34695351]
Fibroblast	IC₅₀	26.3 μM Compound: 1	Cytotoxicity against SMS mutant human CMS-23916 cells in absence of aminoguanidine measured after 72 hrs Cytotoxicity against SMS mutant human CMS-23916 cells in absence of aminoguanidine measured after 72 hrs	[PMID: 34695351]
Fibroblast	IC₅₀	326.7 μM Compound: 1	Cytotoxicity against human wild type CMS-24949 cells in presence of aminoguanidine measured after 72 hrs Cytotoxicity against human wild type CMS-24949 cells in presence of aminoguanidine measured after 72 hrs	[PMID: 34695351]

Chemical Information

CAS No. 2576358-68-2
Molecular Weight 576.00
Formula C₂₄H₄₅Cl₃N₄O₅
SMILES

COC1=C(C(C(C(C)(CC(NCCCNCCCCNCCCN)=O)C)=C(C1=O)C)=O)OC.[H]Cl.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mukund P Tantak, et al. Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. J Med Chem. 2021 Nov 11;64(21):15593-15607. [Content Brief]

[2]. Mukund P Tantak, et al. Development of a Redox-Sensitive Spermine Prodrug for the Potential Treatment of Snyder Robinson Syndrome. J Med Chem. 2021 Nov 11;64(21):15593-15607.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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